PT - JOURNAL ARTICLE AU - Boe, Nils Jensen AU - Hald, Stine Munk AU - Jensen, Mie michelelsen AU - Bojsen, Jonas Asgaard AU - Elhakim, Mohammad Talal AU - Florisson, Sandra AU - Saleh, Alisa AU - Clausen, Anne AU - Möller, Sören AU - Harbo, Frederik Severin gratrae AU - Graumann, Ole AU - Hallas, Jesper AU - García Rodríguez, Luis Alberto AU - Al-Shahi Salman, Rustam AU - Goldstein, Larry B. AU - Gaist，David TI -他汀类药物使用与脑出血部位的关系[ei] . 10.1212/WNL.0000000000201664DP - 2023 07年3月TA -神经学半岛投注体育官网PG - e1048- e1061 VI - 100 IP - 10 4099 - //www.ebmtp.com/content/100/10/e1048.short 4100 - //www.ebmtp.com/content/100/10/e1048.full SO -神经学2023年3月07;背景和目的他汀类药物与脑出血(ICH)的因果关系尚不确定。我们假设长期他汀类药物暴露与脑出血风险之间的关系可能因脑出血部位的不同而不同。方法:我们使用丹麦全国登记系统进行分析。在丹麦南部地区(人口120万)，我们确定了2009年至2018年间年龄≥55岁的所有首次ICH病例。经医疗记录证实诊断的患者分为大叶性或非大叶性脑出血，并根据年龄、性别和日历年与一般人群对照进行匹配。我们使用全国处方登记来确定既往他汀类药物和其他药物的使用情况，并根据近期、持续时间和强度进行分类。通过对潜在混杂因素进行校正的条件逻辑回归，我们计算了大叶性和非大叶性脑出血风险的校正ORs (aORs)和相应的95% ci。结果:我们确定了989例脑叶性脑出血患者(52.2%为女性，平均年龄76.3岁)与39,500例对照相匹配，1175例非脑叶性脑出血患者(46.5%为女性，平均年龄75.1岁)与46,755例对照相匹配。 Current statin use was associated with a lower risk of lobar (aOR 0.83; 95% CI, 0.70–0.98) and nonlobar ICH (aOR 0.84; 95% CI, 0.72–0.98). Longer duration of statin use was also associated with a lower risk of lobar (<1 year: aOR 0.89; 95% CI, 0.69–1.14; ≥1 year to <5 years aOR 0.89; 95% CI 0.73–1.09; ≥5 years aOR 0.67; 95% CI, 0.51–0.87; p for trend 0.040) and nonlobar ICH (<1 year: aOR 1.00; 95% CI, 0.80–1.25; ≥1 year to <5 years aOR 0.88; 95% CI 0.73–1.06; ≥5 years aOR 0.62; 95% CI, 0.48–0.80; p for trend <0.001). Estimates stratified by statin intensity were similar to the main estimates for low-medium intensity therapy (lobar aOR 0.82; nonlobar aOR 0.84); the association with high-intensity therapy was neutral.Discussion We found that statin use was associated with a lower risk of ICH, particularly with longer treatment duration. This association did not vary by hematoma location.aOR=adjusted OR; CAA=cerebral amyloid angiopathy; ICH=intracerebral hemorrhage; IVH=intraventricular hemorrhage; RSD=Region of Southern Denmark; SVD=small vessel disease