A Stasenko, Alena %A Kaestner, Erik %A Arienzo, Donatello %A Schadler, Adam %A Reyes, Anny %A Shih, Jerry %A Helm, Jonathan L %A powczyzynska, Monika %A McDonald, Carrie R %T双语和左颞叶癫痫的结构网络组织:神经疾病的弹性%D 2023 %R 10.1212/WNL。0000000000207087 %J神半岛投注体育官网经病学%P 10.1212/WNL。背景与目标:越来越多的证据表明，双语可以诱导神经可塑性和调节神经效率，从而增强对神经疾病的抵抗力。然而，双语是否有益于癫痫患者的神经健康尚不清楚。我们测试了颞叶癫痫(TLE)双语患者是否改善了全脑结构性白质网络组织。方法:从两个专门的癫痫中心招募的健康对照组和TLE患者完成了扩散加权MRI和神经心理学测试，作为观察队列研究的一部分。通过扩散束成像生成全脑连接体，并使用图论进行分析。全局分析比较了TLE与对照组的网络集成(路径长度)和专门化(传递性)，以及2(左TLE与右TLE) x 2(双语与单语)模型。局部分析比较了预先定义的额叶执行和语言(即近视域)子网络的平均局部效率。探索性相关性检验了网络组织和神经心理表现之间的关系。结果:共有29名双语和88名单语TLE患者在几个人口统计学和临床变量上匹配，以及81名年龄匹配的健康对照。 Globally, a significant interaction between language status and side of seizure onset revealed higher network organization in bilinguals compared to monolinguals, but only in left TLE (LTLE). Locally, bilinguals with LTLE showed higher efficiency in frontal-executive, but not in perisylvian networks compared to LTLE monolinguals. Improved whole-brain network organization was associated with better executive function performance in bilingual but not monolingual LTLE.Discussion: Higher structural network organization in bilingual individuals with LTLE suggests a neuromodulatory effect of bilingualism on whole-brain connectivity in epilepsy, providing evidence for neural reserve. This may reflect attenuation of or compensation for epilepsy-related dysfunction of the left hemisphere, potentially driven by increased efficiency of frontal-executive networks that mediate dual-language control. This highlights a potential role of bilingualism as a protective factor in epilepsy, motivating further research across neurological disorders to define mechanisms and develop interventions. %U //www.ebmtp.com/content/neurology/early/2023/02/28/WNL.0000000000207087.full.pdf