RT杂志文章SR电子T1更新的宾夕法尼亚大学气味识别测试在50岁及以上的成年人JF神经病学JO神经病学FD Lippincott Williams & Wilkins SP 10.1212/WNL.0000000000207077半岛投注体育官网10.1212 / WNL.0000000000207077A1 Brumm, Michael C A1 Pierz, Kerri A. A1 Lafontant, David-Erick A1 Caspell-Garcia, Chelsea A1 Coffey, Christopher S. A1 Siderowf, Andrew A1 Marek, Kenneth YR 2023 UL http://n.半岛投注体育官网neurology.org/content/early/2023/02/27/WNL.0000000000207077.abstract AB背景和目标:宾夕法尼亚大学气味识别测试(UPSIT)通常用于评估嗅觉和筛查疾病的早期检测，包括帕金森病(PD)和阿尔茨海默病。我们的目标是基于比以往规范大得多的样本，制定更新的百分位数，以更精确地区分年龄和性别特异性的UPSIT表现，这些≥50岁的成年人可能是前驱神经退行性疾病研究的候选对象。方法:对2007-2010年至2013-2015年期间招募的帕金森相关风险综合征(PARS)和帕金森进展标志物计划(PPMI)队列研究参与者分别进行了UPSIT横截面测试。排除标准包括年龄<50岁和确诊或疑似PD诊断。收集了PD的人口统计学、家族史和前驱特征，包括自我报告的低血压。规范数据包括均值、标准差和百分位，按年龄和性别推导。结果:分析样本包括9396人(5336名女性，4060名男性)，年龄50-95岁，主要是白人，非西班牙裔美国居民。分别为女性和男性推导并提供了七个年龄类别(50-54、55-59、60-64、65-69、70-74、75-79和≥80)的UPSIT百分位数;相对于现有的标准，亚组包括2.4-20倍的参与者。 Olfactory function declined with age and was better among women than men; accordingly, the percentile corresponding to a given raw score varied markedly by age and sex. UPSIT performance was comparable among individuals with vs without first-degree family history of PD. Comparisons of self-reported hyposmia vs UPSIT percentiles indicated a strong association (chi-squared P<0.0001), but minimal agreement (Cohen’s simple kappa [95% CI]: = 0.32 [0.28-0.36] for females; 0.34 [0.30-0.38] for males).Discussion: Updated age/sex-specific UPSIT percentiles are provided for ≥50-year-old adults who reflect a population likely to be recruited into studies of prodromal neurodegenerative diseases. Our findings highlight the potential advantages of evaluating olfaction relative to age and sex instead of in absolute terms (e.g., based on raw UPSIT scores) or based on subjective (i.e., self-reported) measures. This information addresses the need to support studies of disorders including PD and Alzheimer’s disease by providing updated normative data from a larger sample of older adults.