TY - JOUR T1 -老年人嗅觉与脑容量和神经心理功能纵向轨迹的关联JF - Neurology JO - Neurology SP - e964 LP - e974 DO - 10.1212/WNL.0000000000201646半岛投注体育官网六世- 100 - 9 AU -田盟——杨曲盟梅丽莎·h·Kitner-Triolo盟Christos Davatzikos AU -斯蒂芬妮·a·Studenski盟Luigi费鲁奇盟——Susan m . Resnick Y1 - 2023/02/28 UR - //www.ebmtp.com/content/100/9/e964.abstract N2 -嗅觉功能下降,老半岛投注体育官网龄化的背景和目标,和嗅觉赤字是最早的神经退行性疾病的特点,如帕金森病和阿尔茨海默病。先前的研究表明，嗅觉与脑容量和认知功能有关，但数据完全是横向的。我们旨在研究嗅觉与脑容量和神经心理功能变化的纵向关联。在巴尔的摩老龄化纵向研究中，我们选择了第一次嗅觉评估，使用线性混合效应模型，根据人口统计学变量和心血管疾病调整，来检查50岁或50岁以上参与者的神经心理表现和脑容量的回顾性和前瞻性变化与嗅觉的相关性。嗅觉通过16项嗅探棒的气味识别得分来衡量。我们分析了567名(58%女性，42%男性，27%黑人，66%白人和7%其他)具有气味识别评分和脑容量MRI数据的参与者(n = 420例平均3.7年的回顾性重复，n = 280例平均1.2年的前瞻性重复)的数据。我们还分析了754名参与者(56%女性，44%男性，29%黑人，65%白人和6%其他)进行神经心理学评估的数据(n = 630例平均6.6年的回顾性重复，n = 280例平均1.5年的前瞻性重复)。调整后，较高的气味识别评分与内嗅皮层(β±SE = 0.0093±0.0031,p = 0.0028， β±SE = 0.0176±0.0073,p = 0.0169)、海马区(β±SE = 0.0070±0.0030,p = 0.0192， β±SE = 0.0173±0.0066,p = 0.0089)以及额外的额叶和颞叶区(均p <0.05)。 Higher odor identification scores were also associated with prior slower decline in memory, attention, processing speed, and manual dexterity and subsequent slower decline in attention (all p < 0.05). Some associations were attenuated after exclusion of data points at and after symptom onset of cognitive impairment or dementia.Discussion In older adults, olfaction is related to brain atrophy of specific brain regions and neuropsychological changes in specific domains over time. The observed associations are driven, in part, by those who developed cognitive impairment or dementia. Future longitudinal studies with longer follow-ups are needed to understand whether olfactory decline precedes cognitive decline and whether it is mediated through regionally specific brain atrophy.AD=Alzheimer disease; BLSA=Baltimore Longitudinal Study of Aging; CVLT=California Verbal Learning Test; DSM-III-R=Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised; DSST=Digit Symbol Substitution Test; FDR=false discovery rate; LME=linear mixed effect; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; MPRAGE=magnetization-prepared rapid gradient echo; MUSE=MUlti-atlas region Segmentation using Ensembles; TMT-A=Trail Making Test part A; TMT-B=Trail Making Test part B ER -