PT -期刊文章AU - Amir Khakban AU - elisisabet Rodriguez Llorian AU - Kristina D. Michaux AU - Scott B. Patten AU - Anthony Traboulsee AU - Jiwon Oh AU - Larry D. Lynd AU -代表CanProCo研究小组TI -与多发性硬化症相关的直接医疗保健费用AID - 10.1212/WNL.0000000000201645DP - 2023 2月28日TA -神经学半岛投注体育官网PG - e899- e910 VI - 100 IP - 9 4099 - //www.ebmtp.com/content/100/9/e899.short 4100 - //www.ebmtp.com/content/100/9/e899.full SO -神经学2023 2月28日;背景和目标多发性硬化症(MS)是年轻人非创伤性神经残疾的主要原因，对医疗保健系统造成了巨大的经济负担。本研究的目的是量化加拿大不列颠哥伦比亚省多发性硬化症的额外医疗费用。方法采用2001年至2020年基于人群的行政健康数据，对MS患者进行回顾性匹配队列研究。符合有效病例定义的多发性硬化症患者在性别、年龄和队列进入日期方面与5个没有多发性硬化症的独特对照进行匹配。患者和对照组被跟踪到2020年底或他们最后一次使用卫生保健资源，以先到者为准。我们计算了每个人的直接医疗费用，包括门诊服务使用、住院和分发药物。我们使用具有单位链和正态分布的广义线性模型来估计MS的额外费用，作为MS患者和对照组之间的平均费用差。所有费用均以2020年加拿大元计算。Results A total of 17,071 patients with MS were matched to 85,355 controls. Overall, 72.4% were female, and the mean age at cohort entry date was 46.1 years. The excess cost of MS was $6,881 (95% CI: $6,713, $7,049) per patient-year. Inpatient, outpatient, and medication costs accounted for 25%, 10%, and 65% of excess costs, respectively. Excess costs were higher in patients with MS with at least one disease-modifying therapy (DMT) prescription ($13,267; 95% CI: $12,992–$13,542) compared with non-DMT users ($3,469; 95% CI: $3,297–$3,641) and even higher among frequent DMT users ($24,835; 95% CI: $24,528–$25,141). Patients with MS with a history of at least one relapse requiring hospitalization had higher excess costs ($10,543; 95% CI: $10,136–$10,950) compared with patients with MS without a relapse; hospitalizations accounted for 51% of the costs in this group. The excess cost of hospitalizations was $1,391 lower among frequent DMT users than non-DMT users.Discussion The economic burden of MS is considerable, with medications, particularly DMTs, being the largest cost driver. Future studies should investigate how disease management strategies, including early diagnosis and timely use of DMTs, could offset future and ongoing costs while improving patients' quality of life.DAD=discharge abstract database; DMT=disease-modifying therapy; ICD=International Classification of Diseases; MS=multiple sclerosis; MSP=medical services plan