RT杂志文章SR电子T1 MRI上脉系膜丛炎症与多发性硬化症患者5年以上临床残疾进展的关系JF神经学JO神经学FD Lippincott Williams & Wilkins SP e911 OP e920 DO 10.1212/WNL.0000000000201608半岛投注体育官网VO 100 IS 9 A1 Niels Bergsland A1 Michael G. Dwyer A1 Dejan Jakimovski A1 Eleonora Tavazzi A1 Ralph H.B. Benedict A1 Bianca weinstck - guttman A1 Robert Zivadinov YR 2023 UL http://n半岛投注体育官网.neurology.org/content/100/9/e911.abstract AB背景和目的脉脉络丛炎症(CP)已报道于多发性硬化症(MS)。CP炎症与临床残疾进展之间的AU1相关性仍存在争议。在这项纵向研究的回顾性分析中，174例MS患者(118例复发缓解型MS, 56例进展型MS [PMS])和56例年龄和性别匹配的健康对照(hc)，在基线和平均5.5年的随访后，在3T MRI扫描仪上成像。评估T2病变体积(T2- lv)。计算区域组织体积。测量CP体积，伪t2 (pT2)作图评估CP炎症。组间比较和相关性根据年龄和性别进行了调整。结果与hc相比，MS患者在基线时CP体积显著增大(p = 0.01)， CP pT2显著增加(<0.001)。在MS样本中，CP体积和CP pT2在随访期间没有显著增加。 However, baseline CP pT2 was associated with clinical disability progression at follow-up (p = 0.001), even after controlling for all other factors significantly associated with disability progression (p = 0.030), including T2-LV, normalized brain volume, normalized gray matter volume, and normalized thalamic volumes. Changes in CP volume and CP pT2 were not related to changes in clinical parameters such as relapse rate over the course of the follow-up.Discussion CP inflammation, as evidenced by MRI, is clinically relevant in MS. CP inflammation may have a relevant role in driving disease progression.ANCOVA=analysis of covariance; CP=choroid plexus; EDSS=Expanded Disability Status Scale; ETL=echo train length; GM=gray matter; HC=healthy control; LPM=lesion probability mapping; MS=multiple sclerosis; NBV=normalized brain volume; NCPV=normalized choroid plexus volume; NGMV=normalized gray matter volume; NWMV=normalized white matter volume; NVV=normalized ventricular volume; PMS=progressive MS; PPMS=primary progressive multiple sclerosis; RRMS=relapsing-remitting MS; SPMS=secondary progressive MS; TE=echo time; TI=inversion time; TR=repetition time; VBM=voxel-based morphometry; WM=white matter

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