TY - JOUR T1 - MRI上脉管炎与多发性硬化患者5年以上临床残疾进展的关系JF -神经学JO -神经学SP - e911 LP - e920 DO - 10.1212/WNL.0000000000201608半岛投注体育官网VL - 100 IS - 9 AU - Niels Bergsland AU - Michael G. Dwyer AU - Dejan Jakimovski AU - Eleonora Tavazzi AU - Ralph H.B. Benedict AU - Bianca weinstck - guttman AU - Robert Zivadinov Y1 - 2023/02/28 UR - http://n半岛投注体育官网.neurology.org/content/100/9/e911.abstract N2 -背景和目的脉脉络丛(CP)炎症在多发性硬化症(MS)中有报道。CP炎症与临床残疾进展之间的AU1相关性仍存在争议。在这项纵向研究的回顾性分析中，174例MS患者(118例复发缓解型MS, 56例进展型MS [PMS])和56例年龄和性别匹配的健康对照(hc)，在基线和平均5.5年的随访后，在3T MRI扫描仪上成像。评估T2病变体积(T2- lv)。计算区域组织体积。测量CP体积，伪t2 (pT2)作图评估CP炎症。组间比较和相关性根据年龄和性别进行了调整。结果与hc相比，MS患者在基线时CP体积显著增大(p = 0.01)， CP pT2显著增加(<0.001)。在MS样本中，CP体积和CP pT2在随访期间没有显著增加。 However, baseline CP pT2 was associated with clinical disability progression at follow-up (p = 0.001), even after controlling for all other factors significantly associated with disability progression (p = 0.030), including T2-LV, normalized brain volume, normalized gray matter volume, and normalized thalamic volumes. Changes in CP volume and CP pT2 were not related to changes in clinical parameters such as relapse rate over the course of the follow-up.Discussion CP inflammation, as evidenced by MRI, is clinically relevant in MS. CP inflammation may have a relevant role in driving disease progression.ANCOVA=analysis of covariance; CP=choroid plexus; EDSS=Expanded Disability Status Scale; ETL=echo train length; GM=gray matter; HC=healthy control; LPM=lesion probability mapping; MS=multiple sclerosis; NBV=normalized brain volume; NCPV=normalized choroid plexus volume; NGMV=normalized gray matter volume; NWMV=normalized white matter volume; NVV=normalized ventricular volume; PMS=progressive MS; PPMS=primary progressive multiple sclerosis; RRMS=relapsing-remitting MS; SPMS=secondary progressive MS; TE=echo time; TI=inversion time; TR=repetition time; VBM=voxel-based morphometry; WM=white matter ER -