@文章{Bergslande911，作者= {Niels Bergsland and Michael G. Dwyer and Dejan Jakimovski and Eleonora Tavazzi and Ralph H.B. Benedict and Bianca Weinstock-Guttman and Robert Zivadinov}，标题={脉膜丛炎症在MRI上与多发性硬硬症患者5年内临床残疾进展的相关性}，卷={100}，数={9}，页= {e911—e920}，年= {2023}，doi = {10.1212/WNL。0000000000201608}，出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会}，摘要={背景和目的脉络膜丛(CP)炎症已在多发性硬化症(MS)中报道半岛投注体育官网。CP炎症与临床残疾进展之间的AU1相关性仍存在争议。在这项纵向研究的回顾性分析中，174例MS患者(118例复发缓解型MS, 56例进展型MS [PMS])和56例年龄和性别匹配的健康对照(hc)，在基线和平均5.5年的随访后，在3T MRI扫描仪上成像。评估T2病变体积(T2- lv)。计算区域组织体积。测量CP体积，伪t2 (pT2)作图评估CP炎症。组间比较和相关性根据年龄和性别进行了调整。结果与hc相比，MS患者在基线时CP体积显著增大(p = 0.01)， CP pT2显著增加(\<0.001)。在MS样本中，CP体积和CP pT2在随访期间没有显著增加。然而，基线CP pT2在随访时与临床残疾进展相关(p = 0.001)，即使控制了与残疾进展显著相关的所有其他因素(p = 0.030)，包括T2-LV、归一化脑容量、归一化灰质容量和归一化丘脑容量。 Changes in CP volume and CP pT2 were not related to changes in clinical parameters such as relapse rate over the course of the follow-up.Discussion CP inflammation, as evidenced by MRI, is clinically relevant in MS. CP inflammation may have a relevant role in driving disease progression.ANCOVA=analysis of covariance; CP=choroid plexus; EDSS=Expanded Disability Status Scale; ETL=echo train length; GM=gray matter; HC=healthy control; LPM=lesion probability mapping; MS=multiple sclerosis; NBV=normalized brain volume; NCPV=normalized choroid plexus volume; NGMV=normalized gray matter volume; NWMV=normalized white matter volume; NVV=normalized ventricular volume; PMS=progressive MS; PPMS=primary progressive multiple sclerosis; RRMS=relapsing-remitting MS; SPMS=secondary progressive MS; TE=echo time; TI=inversion time; TR=repetition time; VBM=voxel-based morphometry; WM=white matter}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/100/9/e911}, eprint = {//www.ebmtp.com/content/100/9/e911.full.pdf}, journal = {Neurology} }