PT -期刊文章AU -杨,植绒AU -魏,张非盟-李,小娟盟——元,金秋AU -高,雪峰AU - Li Bingyu盟——赵,章子怡盟——(Sengwee AU - Yu,鑫盟,Brayne卡罗尔AU -杨,Zuyao AU -沙,风盟——唐,金陵TI -定期使用泻药和事件之间的联系在英国生物库痴呆- 10.1212 / WNL参与者援助。0000000000207081 DP - 2023年2月22日TA -神经病半岛投注体育官网学PG - 10.1212 / WNL。0000000000207081 4099 - http://n.半岛投注体育官网neurology.org/content/early/2023/02/22/WNL.0000000000207081.short 4100 - //www.ebmtp.com/content/early/2023/02/22/WNL.0000000000207081.full AB -背景和目标场外泻药的使用在一般人群中很常见。microbiome-gut-brain轴假说表明使用泻药与痴呆有关。我们旨在研究之间的关系经常使用泻药和痴呆的发病率在英国生物库的参与者。方法前瞻性群组研究是基于40到69岁的英国生物库的参与者没有痴呆的历史。经常使用泻药被定义为自我报告的使用在大多数天星期过去4周的基线(2006 - 2010)。结果是全因痴呆、阿尔茨海默病和血管性痴呆,确定从联系住院或死亡登记(2020)。Socio-demographic特点、生活方式因素、医疗条件、家庭历史和常规药物的使用调整的多变量Cox回归分析。结果502229名参与者的平均年龄56.5在基线(SD = 8.1), 273251(54.4%)是女性,18235(3.6%)报告定期使用泻药。在一个平均9.8年的随访中,218(1.3%)的参与者经常使用泻药和1969(0.4%)与不定期使用发达全因痴呆。多变量分析表明,经常使用泻药,因各种原因引起的痴呆风险(风险比[HR] 1.51; 95% confidence interval 1.30-1.75) and vascular dementia (HR 1.65; 1.21-2.27), with no significant association observed for Alzheimer’s disease (HR 1.05; 0.79-1.40). The risk of both all-cause dementia and vascular dementia increased with the number of regularly used laxative types (P-trend 0.001 and 0.04, respectively). Among the participants who clearly reported that they were using just one type of laxative (n=5800), only those using osmotic laxatives showed a statistically significantly higher risk of all-cause dementia (HR 1.64 [1.20-2.24]) and vascular dementia (HR 1.97 [1.04-3.75]). These results remained robust in various subgroup and sensitivity analyses.Discussion Regular use of laxatives was associated with a higher risk of all-cause dementia, particularly in those who used multiple laxative types or osmotic laxative.

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