%0期刊文章%杨志荣%魏志荣%李畅%A，袁晓娟%A，高金秋%A，李雪峰%A，赵冰玉%A，紫怡%A Toh, Sengwee %A Yu, Xin %A Brayne, Carol %A Yang, Zuyao %A Sha, Feng %A Tang，金玲%T英国生物银行参与者定期使用通便剂与痴呆发病的关系%D 2023 %R 10.1212/WNL。0000000000207081神经病学半岛投注体育官网%P 10.1212/WNL。背景和目标非处方泻药在普通人群中普遍使用。微生物群-肠道-脑轴假说表明，服用泻药与痴呆症有关。我们旨在研究英国生物银行参与者中定期使用泻药与痴呆症发病率之间的关系。这项前瞻性队列研究基于英国生物银行参与者，年龄在40岁至69岁之间，无痴呆史。常规使用泻药的定义为基线时(2006-2010年)过去4周内每周大部分时间自我报告使用泻药。结果是全因痴呆、阿尔茨海默病和血管性痴呆，从相关住院或死亡登记中确定(截至2020年)。在多变量Cox回归分析中，对社会人口学特征、生活方式因素、医疗条件、家族史和常规用药进行了调整。在基线时平均年龄为56.5岁(SD=8.1)的502229名参与者中，273,251名(54.4%)为女性，18,235名(3.6%)报告经常使用泻药。在平均9.8年的随访中，218名(1.3%)经常服用泻药的参与者和1969名(0.4%)不经常服用泻药的参与者患上了全因痴呆。多变量分析显示，经常服用泻药与全因痴呆风险增加相关(风险比[HR] 1.51; 95% confidence interval 1.30-1.75) and vascular dementia (HR 1.65; 1.21-2.27), with no significant association observed for Alzheimer’s disease (HR 1.05; 0.79-1.40). The risk of both all-cause dementia and vascular dementia increased with the number of regularly used laxative types (P-trend 0.001 and 0.04, respectively). Among the participants who clearly reported that they were using just one type of laxative (n=5800), only those using osmotic laxatives showed a statistically significantly higher risk of all-cause dementia (HR 1.64 [1.20-2.24]) and vascular dementia (HR 1.97 [1.04-3.75]). These results remained robust in various subgroup and sensitivity analyses.Discussion Regular use of laxatives was associated with a higher risk of all-cause dementia, particularly in those who used multiple laxative types or osmotic laxative. %U //www.ebmtp.com/content/neurology/early/2023/02/22/WNL.0000000000207081.full.pdf