Raffaelli, Bianca Storch, Elisabeth Overeem, Lucas Hendrik, Maria Fitzek, Mira Pauline, A Lange, Kristin Sophie, A Reuter，女性偏头痛患者性激素和降钙素基因相关肽:一项横向匹配队列研究。0000000000207114 %J神半岛投注体育官网经病学%P 10.1212/WNL。背景和目的:性激素可能调节三叉血管系统中CGRP的释放。我们研究了患有周期性偏头痛(EM)和月经周期正常(RMC)的女性参与者、患有EM并联合口服避孕药(COC)的女性参与者以及绝经后患有EM的女性参与者血浆和泪液中CGRP的浓度。作为对照，我们分析了三组没有em的年龄匹配的女性参与者。方法:有RMC的参与者有两次就诊:月经周期第2天±2日的月经期间和第13天±2日的排卵期。COC患者在无激素间隔(HFI)的第4±2天和激素摄入(HI)的第7-14天进行检查。在随机时间点对绝经后参与者进行了一次评估。每次就诊均收集血浆和泪液样本，用酶联免疫吸附法测定CGRP水平。结果:共有180名女性参与者(每组30名)完成了研究。与无偏头痛的女性参与者相比，患有偏头痛和RMC的参与者在月经期间血浆和泪液中CGRP浓度有统计学意义上的显著升高[血浆:5.95 pg/ml (IQR 4.37 - 10.44) vs. 4.61 pg/ml (IQR 2.83 - 6.92)， p=0.020 (Mann-Whitney U检验);泪液:1.20 ng/ml (IQR 0.36 - 2.52) vs. 0.4 ng/ml (IQR 0.14 - 1.22)， p=0.005 (Mann-Whitney U检验)]。相比之下，患有COC和绝经后的女性参与者在偏头痛组和对照组中具有相似的CGRP水平。 In migraine participants with a RMC, tear fluid but not plasma CGRP concentrations during menstruation were statistically significantly higher compared to migraine participants under COC (p=0.015 vs. HFI and p=0.029 vs. HI, Mann-Whitney U test).Discussion: Different sex hormone profiles may influence CGRP concentrations in people, with current or past capacity to menstruate, with migraine. Measurement of CGRP in tear fluid was feasible and warrants further investigation. %U //www.ebmtp.com/content/neurology/early/2023/02/22/WNL.0000000000207114.full.pdf