@article {Raffaelli10.1212 / WNL。0000000000207114，作者= {Raffaelli, Bianca和Storch, Elisabeth和Overeem, Lucas Hendrik和Terhart, Maria和Fitzek, Mira Pauline和Lange, Kristin Sophie和Reuter, Uwe}，标题={女性偏头痛性激素和降钙素基因{\textendash}相关肽:一个横断，匹配队列研究}，定位-id = {10.1212/WNL。0000000000207114}， year = {2023}， doi = {10.1212/WNL。0000000000207114}，出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会}，摘要={背景和目的:性激素可能调节三叉血管系统中CGRP的释放。半岛投注体育官网我们研究了患有周期性偏头痛(EM)和月经周期正常(RMC)的女性参与者、患有EM并联合口服避孕药(COC)的女性参与者以及绝经后患有EM的女性参与者血浆和泪液中CGRP的浓度。方法:有RMC的参与者有两次就诊:在月经周期第2天月经期间和第13天排卵期{\textpm} 2。COC患者在无激素间隔期(HFI)第4天和激素摄入(HI)第7-14天进行检查。在随机时间点对绝经后参与者进行了一次评估。每次就诊均收集血浆和泪液样本，用酶联免疫吸附法测定CGRP水平。结果:共有180名女性参与者(每组30名)完成了研究。与无偏头痛的女性参与者相比，患有偏头痛和RMC的参与者在月经期间的血浆和泪液中CGRP浓度有统计学意义上的显著升高[血浆:5.95 pg/ml (IQR 4.37 {\textendash} 10.44) vs. 4.61 pg/ml (IQR 2.83 {\textendash} 6.92)， p=0.020 (Mann-Whitney U检验);泪液:1.20 ng/ml (IQR 0.36 {\textendash} 2.52) vs. 0.4 ng/ml (IQR 0.14 {\textendash} 1.22)， p=0.005 (Mann-Whitney U检验)]。 In contrast, female participants with COC and in the postmenopause had similar CGRP levels in the migraine and the control groups. In migraine participants with a RMC, tear fluid but not plasma CGRP concentrations during menstruation were statistically significantly higher compared to migraine participants under COC (p=0.015 vs. HFI and p=0.029 vs. HI, Mann-Whitney U test).Discussion: Different sex hormone profiles may influence CGRP concentrations in people, with current or past capacity to menstruate, with migraine. Measurement of CGRP in tear fluid was feasible and warrants further investigation.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/02/22/WNL.0000000000207114}, eprint = {//www.ebmtp.com/content/early/2023/02/22/WNL.0000000000207114.full.pdf}, journal = {Neurology} }