% 0期刊文章%一个Orrin Devinsky美芯Taquet % % % j .海伦十字阿尔森Paul j .哈里森% % T癫痫和癫痫的发病率在前6个月后COVID-19诊断% B回顾性队列研究% D R 10.1212 / WNL 2023%。0000000000201595 % J半岛投注体育官网神经病学% P e790-e799 % V 100% N 8% X背景和目标COVID-19与癫痫的关系是不确定的。我们研究了潜在的关联COVID-19癫痫和癫痫发作或感染后6个月。方法我们应用验证电子健康记录网络(TriNetX Analytics)的8100万人。我们密切匹配人们COVID-19感染流感。在每一个群体,我们测量了发病率和危险比率(小时)癫痫发作和癫痫。我们按年龄分层数据,是否在住院急性感染的人。然后我们探讨了时变小时发作或癫痫诊断的评估时间模式。我们分析了860934个电子健康记录结果。匹配后,这产生了2组152754例。COVID-19与癫痫发作和癫痫与流感的风险增加。癫痫的发病率在6个月内的COVID-19为0.81% (95% CI 0.75 - -0.88; HR compared with influenza 1.55 [1.39–1.74]). The incidence of epilepsy was 0.30% (0.26–0.34; HR compared with influenza 1.87 [1.54–2.28]). The HR of epilepsy after COVID-19 compared with influenza was greater in people who had not been hospitalized and in individuals younger than 16 years. The time of peak HR after infection differed by age and hospitalization status.Discussion The incidence of new seizures or epilepsy diagnoses in the 6 months after COVID-19 was low overall, but higher than in matched patients with influenza. This difference was more marked in people who were not hospitalized, highlighting the risk of epilepsy and seizures even in those with less severe infection. Children appear at particular risk of seizures and epilepsy after COVID-19 providing another motivation to prevent COVID-19 infection in pediatric populations. That the varying time of peak risk related to hospitalization and age may provide clues as to the underlying mechanisms of COVID-associated seizures and epilepsy.CPT=Current Procedural Terminology; HRs=hazard ratios; HCOs=healthcare organizations; ICD=International Classification of Diseases; PNES=psychological nonepileptic attacks %U //www.ebmtp.com/content/neurology/100/8/e790.full.pdf