TY - T1的血液生物标志物的有效性和性能预测阿尔茨海默病痴呆风险大的诊断群组JF -神经学乔-神经病学SP - e473 LP - e484做- 10.1212 / WNL。半岛投注体育官网0000000000201479六世- 100 - 5盟Planche文森特盟——Bouteloup文森特AU - Pellegrin,伊莎贝尔盟-曼京,让非盟-杜布瓦,布鲁诺盟——Ousset Pierre-Jean盟——Pasquier佛罗伦萨AU -布兰科,克莱尔盟——Hanon Frederic AU - Paquet Olivier AU -本尼,卡里姆盟——Ceccaldi马修AU - Annweiler,塞德里克盟——Krolak-Salmon皮埃尔盟——Godefroy Olivier盟——Wallon大卫AU - Sauvee,马蒂尔德盟——Boutoleau-Bretonniere克莱尔AU - Bourdel-Marchasson,伊莎贝尔盟Jalenques,伊莎贝尔盟Chene,吉纳维芙盟——Dufouil卡罗尔盟,Y1 - 2023/01/31 UR - //www.ebmtp.com/content/100/5/e473.abstract N2 -背景和客观的血液生物标志物对阿尔茨海默病(AD)一直被证明是与CSF或宠物相关生物标志物和有效区分广告与其他神经退行性疾病。半岛投注体育官网我们的目的是测试他们的效用在临床实践中,从一个多中心没有前瞻性群组,患者遇到一个大范围的认知缺陷或投诉。方法纪念品队列招募了2323名门诊病人主观认知投诉(SCC)或轻度认知障碍(MCI)咨询在26日法国记忆诊所。参与者神经心理评估、核磁共振和血液采样在基线。CSF采样和淀粉样宠物是可选的。基线血液Aβ42/40比率、总τ,p181-tau,神经丝轻链(NfL)测量使用Simoa HD-X分析仪。一个专家委员会验证事件痴呆病例5年随访期间。结果总的来说,2277人至少有1基线可用血液生物标志物(n = 357 CSF子样品,宠物子样品n = 649),其中257人被诊断出患有痴呆临床AD /混合在随访中。所有血液生物标志物但总τ是温和与等价的CSF (r = 0.33 ~ 0.46, p & lt;0.0001)和与淀粉pet状态有关(p & lt; 0.0001). Blood p181-tau was the best blood biomarker to identify amyloid-PET positivity (area under the curve = 0.74 [95% CI = 0.69; 0.79]). Higher blood and CSF p181-tau and NfL concentrations were associated with accelerated time to AD dementia onset with similar incidence rates, whereas blood Aβ42/40 was less efficient than CSF Aβ42/40. Blood p181-tau alone was the best blood predictor of 5-year AD/mixed dementia risk (c-index = 0.73 [95% CI = 0.69; 0.77]); its accuracy was higher in patients with clinical dementia rating (CDR) = 0 (c-index = 0.83 [95% CI = 0.69; 0.97]) than in patients with CDR = 0.5 (c-index = 0.70 [95% CI = 0.66; 0.74]). A “clinical” reference model (combining demographics and neuropsychological assessment) predicted AD/mixed dementia risk with a c-index = 0.88 [95% CI = 0.86–0.91] and performance increased to 0.90 [95% CI = 0.88; 0.92] when adding blood p181-tau + Aβ42/40. A “research” reference model (clinical model + apolipoprotein E genotype and AD signature on MRI) had a c-index = 0.91 [95% CI = 0.89–0.93] increasing to 0.92 [95% CI = 0.90; 0.93] when adding blood p181-tau + Aβ42/40. Chronic kidney disease and vascular comorbidities did not affect predictive performances.Discussion In a clinic-based cohort of patients with SCC or MCI, blood biomarkers may be good hallmarks of underlying pathology but add little to 5-year dementia risk prediction models including traditional predictors.Aβ=β-amyloid peptide; AD=Alzheimer disease; AUC=area under the curve; ApoE=apolipoprotein E; CDR=Clinical Dementia Rating; eGFR=estimated glomerular filtration rate; MCI=mild cognitive impairment; NfL=neurofilament light chain; ROC=receiver operating characteristic; SCC=subjective cognitive complaint; SUVR=standard uptake value ratio; TMT=Trail Making Test ER -