PT -期刊文章AU -张瑞杰-刘慧娜-朴丽媛-赵田-张顺-韩坤-韩丽媛-韩丽媛- TI .全球204个国家和地区的年轻人缺血性卒中负担[j] .中国医学工程学报，10.1212/WNL.0000000000201467DP - 2023 Jan 24 TA - 半岛投注体育官网Neurology PG - e422—e434 VI - 100 IP - 4 4099 - //www.ebmtp.com/content/100/4/e422.short 4100 - //www.ebmtp.com/content/100/4/e422.full SO - Neurology2023 Jan 24;背景和目的在204个国家和地区按性别、年龄组和社会人口指数(SDI)估计15-49岁年轻人缺血性卒中的发病率、死亡率和伤残调整生命年(DALYs)及其相关危险因素。方法使用2019年全球疾病、损伤和风险因素负担(GBD)研究的数据。计算估算的年百分比变化(EAPCs)以评估1990 - 2019年的时间趋势。我们还估计了导致缺血性卒中DALYs的危险因素。结果从1990年到2019年，全球青年会缺血性卒中的年龄标准化发病率(EAPC = - 0.97)、死亡率(EAPC = - 0.11)和DALYs率(EAPC = - 0.55)下降。年龄标准化发病率、死亡率和DALYs率的最大增幅出现在低和中低SDI五分位数。在区域一级，北非、中东和东南亚在缺血性卒中的年龄标准化发病率、死亡率和伤残调整生命年率方面的增幅最大。2019年，年轻女性的年龄标准化发病率高于年轻男性。在全球范围内，高环境温度、高体重指数(BMI)和高空腹血糖是1990年至2019年期间年龄标准化DALYs率增幅最大的原因。 In the same period, the largest increases in the age-standardized DALYs rates in high-SDI and low-SDI regions were attributable to high environmental temperatures and alcohol use, respectively.Discussion The burden of ischemic stroke in young adults continues to increase in low-SDI regions such as North Africa and the Middle East and Southeast Asia. There were differences in the primary risk factors related to the burden of ischemic stroke in different SDI regions. Targeted implementation of cost-effective policies and interventions is an urgent need to reduce the burden of ischemic stroke in young adults.BMI=body mass index; CI=confidence interval; CODEm=Cause of Death Ensemble modeling; DALYs=disability-adjusted life years; ICD=International Classification of Diseases; EAPCs=estimated annual percentage changes; GBD=Global Burden of Disease; GHDx=Global Health Data Exchange; LDL=low-density lipoprotein; LMIC=low- and middle-income country; SDI=sociodemographic index; TMREL=theoretical minimum risk exposure level; UIs=uncertainty intervals; VA=verbal autopsy; VR=vital registration; WHO=World Health Organization