j - JOUR T1 -芬兰动脉瘤性蛛网膜下腔出血患者病死率[j] - Neurology - JO - Neurology SP - e348 LP - e356 DO - 10.1212/半岛投注体育官网WNL.0000000000201402背景和目的虽然单中心研究报告了动脉瘤性蛛网膜下腔出血(SAH)的病死率(CFRs)下降，但全国性的报告，包括长时间不间断研究期间的猝死性蛛网膜下腔出血(SAH)仍然有限。半岛投注体育官网此外，对于SAH CFR的时间依赖性趋势是否因年龄和/或性别而异，我们知之甚少。因此，我们的目的是表征1998年至2017年芬兰全国SAH cfr的变化。方法:我们使用2个外部验证的全国登记册来识别1998-2017年芬兰所有住院和非住院(猝死)动脉瘤性SAH事件。除了总体30天CFRs外，我们还确定了SAH住院患者中突然死亡和30天CFRs的年比例。为了估计随时间变化的趋势，我们计算了经年龄和性别调整的CFR年度变化(百分比，95% ci)。结果1998年至2017年，我们共发现9443例SAH病例(57.6%为女性)，其中2245例(23.8%)在住院前死亡，3715例(39.3%)在SAH后30天内死亡。在7198例SAH住院患者中，30天CFR为20.4%。在研究期间，总体年龄和性别调整后的CFR平均每年下降1.8%(1.1%-2.6%)。 The decreases were especially notable in the proportion of sudden deaths among middle-aged (aged 40–64 years) and older (aged 65 years or older) women (2.9% [1.1%–4.7%] and 2.3% [0.7%–4.0%] per year, respectively) and in the CFRs of hospitalized young (younger than 40 years) and middle-aged women (9.1% [2.3%–15.7%] and 4.3% [2.3%–6.5%] per year, respectively). On the contrary, the 30-day CFR of older (aged 65 years or older) hospitalized men increased by 3.5% (0.7%–6.3%) per year, while the proportions of older men who died before hospitalization remained unchanged.Discussion The overall CFR of SAH seems to be decreasing, at least among women. The continued high CFR of hospitalized older men requires attention from clinicians and epidemiologists, especially if this trend is also common in other countries.CDR=Cause of Death Register; CFR=case fatality rate; CRHC=Care Register for Health Care; ICD-10=10th revision of the International Classification of Disease; PPV=positive predictive value; RR=risk ratio; SAH=subarachnoid hemorrhage; SBP=systolic blood pressure ER -