RT杂志文章SR电子T1的影响和危险因素边缘显性年龄相关TDP-43脑病神经病理改变在最老队列JF神经学JO神经学FD Lippincott Williams & Wilkins SP e203 OP e210 DO 10.1212/WNL.0000000000201345半岛投注体育官网签证官100 2 A1赛义德Ahmad Sajjadi A1赛义德·布哈里A1齐亚娜a Scambray A1瑞燕A1克劳迪娅川A1 Thomas j . Montine A1玛丽亚·m·Corrada年2023 UL //www.ebmtp.com/content/100/2/e203.abstract 半岛投注体育官网AB背景和目标边缘主要与年龄相关的焦油DNA结合蛋白43 (TDP-43)脑病neuropathologic病理(LATE-NC)是一种普遍的退行性变化的长寿老人的人口中增长最快的细分与痴呆的发病率最高。我们的目的是确定LATE-NC与认知障碍之间的关系，并通过研究其与老年队列中常见病史的关系来确定其潜在的危险因素。方法纳入具有纵向评估和尸检数据的90+研究参与者。痴呆状态和5个主要认知领域的损伤在死后会议上确定，利用所有临床和神经心理学数据，不考虑神经病理学诊断。病史信息来自患者及其举报人。根据NIA-AA指南，海马和/或新皮层TDP-43病理和ADNC高可能性患者分别被认为存在LATE-NC和阿尔茨海默病神经病理改变(ADNC)。我们使用logistic回归对死亡年龄、性别和教育程度进行了调整，检验了退行性病理与认知结果的相关性，以及病史变量与LATE-NC和ADNC的多重比较调整关系。结果本研究共纳入328名受试者。32%的参与者存在LATE-NC。它与痴呆(OR 2.8, 95% CI 1.7-4.6)、记忆障碍(OR 3.0, 95% CI 1.8-5.1)、语言障碍(OR 2.6, 95% CI 1.6-4.3)和定向障碍(OR 3.5, 95% CI 2.1-5.9)有显著相关性。与定向障碍的关联是LATE-NC所特有的，其他关联的强度和意义与ADNC相当。 Furthermore, we found that history of osteoarthritis (OR 0.37, adjusted 95% CI 0.21–0.66) and hypertension (OR 0.52, adjusted 95% CI 0.28–0.98) were associated with a reduced likelihood of LATE-NC, but not ADNC.Discussion Our results suggest that LATE-NC is a prevalent degenerative pathology in the oldest-old and has significant associations with dementia and impairment in cognitive domains with magnitudes that are comparable to ADNC. We also found that past medical histories of hypertension and osteoarthritis were associated with a lower likelihood of LATE-NC. This might help identify upstream mechanisms leading to this important pathology.ADNC=Alzheimer disease neuropathologic change; CAA=cerebral amyloid angiopathy; FTD=frontotemporal dementia; HS=hippocampal sclerosis of aging; LATE=limbic predominant age-related TDP-43 encephalopathy; LATE-NC=LATE neuropathologic change; LWCS=Leisure World Cohort Study; MMSE=Mini Mental State Examination; MVL=microvascular lesion; TDP-43=TAR DNA binding protein 43; UC=University of California

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