PT -期刊文章盟杨怡饰大肠埃文斯AU -玛丽亚j . Knol AU -佩特拉Schwingenschuh盟凯瑟琳Wittfeld AU -希拉尔萨马盟m . Arfan AU - Florian Dubost盟的Ikram Kimberlin m . h . van Wijnen AU -佩特拉Katschnig盟Pinar Yilmaz AU -玛伦德Bruijne盟穆罕默德有非盟-克里斯托弗·陈盟snoke兰格AU -亨利Volzke AU - m . Kamran盟的Ikram汉斯·j .主观能动性AU -莱因霍尔德施密特盟Hieab第三世亚当斯盟Meike w . Vernooij TI -血管周的空间的决定因素一般人口援助- 10.1212/WNL.0000000000201349DP - 2023 1月10日TA -神经学半岛投注体育官网PG - e107—e122 VI - 100 IP - 2 4099 - //www.ebmtp.com/content/100/2/e107.short 4100 - //www.ebmtp.com/content/100/2/e107.full SO -神经学2023 1月10日;背景和目的血管周围间隙(PVS)是脑血管疾病(CSVD)的新兴标志物，但对其决定因素的研究一直受到使用异质评定方法的小型单一研究结果相互矛盾的阻碍。因此，在本研究中，我们旨在通过使用统一的PVS评分方法对多队列研究进行汇总分析，以确定PVS负担的决定因素。方法纳入来自Virchow-Robin空间扩大联盟统一神经成像和英国生物银行的10个以人群为基础的成人队列研究的个体。在MRI扫描中，我们根据统一且经过验证的评分协议(手动和自动使用深度学习算法)计算了4个大脑区域(中脑、海马、基底节区和半椎体)的PVS。作为潜在的决定因素，我们考虑了人口统计学、心血管危险因素、APOE基因型和其他CSVD影像学标志物。负二项回归模型用于检验这些决定因素与PVS计数之间的关系。结果共纳入39976例，年龄20 ~ 96岁。4个地区的平均PVS数从20岁(0 ~ 1 PVS)增加到90岁(2 ~ 7 PVS)。 Men had more mesencephalic PVS (OR [95% CI] = 1.13 [1.08–1.18] compared with women), but less hippocampal PVS (0.82 [0.81–0.83]). Higher blood pressure, particularly diastolic pressure, was associated with more PVS in all regions (ORs between 1.04–1.05). Hippocampal PVS showed higher counts with higher high-density lipoprotein cholesterol levels (1.02 [1.01–1.02]), glucose levels (1.02 [1.01–1.03]), and APOE ε4-alleles (1.02 [1.01–1.04]). Furthermore, white matter hyperintensity volume and presence of lacunes were associated with PVS in multiple regions, but most strongly with the basal ganglia (1.13 [1.12–1.14] and 1.10 [1.09–1.12], respectively).Discussion Various factors are associated with the burden of PVS, in part regionally specific, which points toward a multifactorial origin beyond what can be expected from PVS-related risk factor profiles. This study highlights the power of collaborative efforts in population neuroimaging research.ASPS=Austrian Stroke Prevention Study; BMI=body mass index; CSVD=cerebral small vessel disease; EDIS=Epidemiology of Dementia in Singapore; FLAIR=fluid-attenuated inversion recovery; HDL=high-density lipoproteins; ICC=intraclass correlation coefficient; ICV=intracranial volume; PVS=perivascular spaces; RS=Rotterdam Study; SHIP=Study of Health in Pomerania; UKB=UK Biobank; WM=white matter; WMH=WM hyperintensity