@article {Kamagatae2648作者= {Koji Kamagata和克里斯蒂娜Andica Kaito Takabayashi Yuya Saito和Toshiaki Taoka Hayato Nozaki Junko Kikuta和Shohei Fujita Akifumi Hagiwara和Kouhei Kamiya和Akihiko和田Toshiaki明石和大友Sano第三Nishizawa渡边Hori和真嗣Naganawa Shigeki青木和{\ textquoteright}年代老年痴呆症神经影像倡议},title = {Glymphatic MRI指数协会系统淀粉样蛋白沉积和认知在轻度认知障碍和阿尔茨海默病},体积={99}={24},页面= {e2648——e2660} = {2022}, doi = {10.1212 / WNL。出版商0000000000201300}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标glymphatic系统是整个大脑血管周的网络,促进CSF /间质液半岛投注体育官网交换。改变这个系统可能发挥关键作用的β淀粉样蛋白(Aβ)积累。然而,它参与阿尔茨海默病(AD)发病机制并不完全理解。在这里,我们调查了无创性磁共振成像测量的变化相关的血管周的网络在轻度认知障碍(MCI)患者和广告。此外,我们探讨了MRI措施与神经心理协会得分,宠物标准摄入值比率(SUVR), Aβ沉积。核磁共振方法措施,包括血管周的空间(pv)体积分数(PVSVF),自由水的体积分数白质(FW-WM)和索引的扩散系数沿血管周的空间(阿尔卑斯山脉指数)的MCI患者,那些广告,和健康对照组{\ textquoteright}年代老年痴呆症神经影像倡议数据库进行了比较。MRI措施也与脑脊液生物标志物的水平,宠物SUVR,和认知得分结合subcohort的MCI患者和广告。统计分析与年龄、性别、多年的教育,和APOE身份的混杂因素。结果总共36个广告,患者44 MCI患者和健康对照组31日进行了分析。广告有显著较高的患者,WM和基底神经节PVSVF(科恩d = 1.15 {\ textendash} 1.48;科恩\ p < 0.001)和FW-WM (d = 0.73; p \< 0.05) and a lower ALPS index (Cohen d = 0.63; p \< 0.05) than healthy controls. Meanwhile, the MCI group only showed significantly higher total (Cohen d = 0.99; p \< 0.05) and WM (Cohen d = 0.91; p \< 0.05) PVSVF. Low ALPS index was associated with lower CSF Aβ42 (rs = 0.41, pfdr = 0.026), FDG-PET uptake (rs = 0.54, pfdr \< 0.001), and worse multiple cognitive domain deficits. High FW-WM was also associated with lower CSF Aβ42 (rs = -0.47, pfdr = 0.021) and worse cognitive performances.Discussion Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. We also report the associations between MRI parameters and Aβ deposition, neuronal change, and cognitive impairment in AD.Aβ=amyloid β; ADAS=Alzheimer{\textquoteright}s Disease Assessment Scale; ADNI=Alzheimer{\textquoteright}s Disease Neuroimaging Initiative; ALPS=diffusivity along the perivascular space; BG=basal ganglia; CDR-SB=Clinical Dementia Rating Scale Sum of Boxes; DBP=diastolic blood pressure; DTI=diffusion tensor imaging; DW=diffusion weighted; FA=fractional anisotropy; FAQ=Functional Activities Questionnaire; FDG=[18F] fluorodeoxyglucose; FLAIR=fluid-attenuated inversion recovery; FSL=FMRIB Software Library 6.0.3; FW=free water; GBCA=gadolinium-based contrast agent; GMVF=gray matter volume fraction; Hipp=hippocampus; HMSCORE=Modified Hachinski Ischemic Score; ISF=interstitial fluid; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PVS=perivascular space; PVSVF=PVS volume fraction; RAVLT=Rey Auditory Verbal Learning Test; ROI=region of interest; SBP=systolic blood pressure; SUVR=standardized uptake value ratio; T1w=T1 weighted; WM=white matter; WML=white matter lesion; WMLVF=white matter lesion volume fraction; WMVF=white matter volume fraction}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/99/24/e2648}, eprint = {//www.ebmtp.com/content/99/24/e2648.full.pdf}, journal = {Neurology} }