TY -的T1 -脑代谢与轻度认知障碍和Phenoconversion隔离患者REM睡眠行为障碍的JF -神经学乔-神经病学SP - e2413 LP - e2424做- 10.1212 / WNL。半岛投注体育官网0000000000200326六世- 98 - 24 AU - Eun金Yoon AU - Jee-Young李盟Heejung金盟Dallah Yoo盟荣格圆Shin AU - Hyunwoo南盟Beomseok全金盟- Yu Kyeong Y1 - 2022/06/14 UR - //www.ebmtp.com/content/98/24/e2413.abstract N2 -背景和目标轻度认半岛投注体育官网知障碍(MCI)的孤立的REM睡眠行为障碍(iRBD)是一个后续的神经退化的危险因素。我们旨在识别脑代谢和功能连通性变化与MCI患者iRBD和神经影像学标记phenoconversion的预测价值。方法这是一个前瞻性群组研究iRBD患者平均随访4.2±2.6年。患者在基线,iRBD和年龄,sex-matched健康对照组(高碳钢)经历了18 f-fluorodeoxyglucose (FDG) pet和静息状态功能磁共振成像扫描和全面的神经心理学测试电池。Voxel-wise组比较正数据使用一般线性模型进行。Seed-based连接地图计算使用大脑区域显示显著的代谢减退与MCI患者iRBD和对比组。Cox回归分析应用于调查phenoconversion的脑代谢和风险之间的联系。结果40 iRBD患者,包括21与MCI (iRBD-MCI)和19认知正常(iRBD-NC)和24高碳钢纳入研究。iRBD-MCI组显示相对代谢减退顶叶小叶,外侧和内侧枕,中、下颞叶皮层双边而HC和iRBD-NC组。iRBD-MCI集团在seed-based连通性分析表现出减少功能连通性的左角回枕叶皮层。 Of 40 patients with iRBD, 12 patients converted to Parkinson disease (PD) or dementia with Lewy bodies (DLB). Hypometabolism of the occipital pole (hazard ratio [95% CI] 6.652 [1.387–31.987]), medial occipital (4.450 [1.143–17.327]), and precuneus (3.635 [1.009–13.093]) was associated with higher phenoconversion rate to PD/DLB.Discussion MCI in iRBD is related to functional and metabolic changes in broad brain areas, particularly the occipital and parietal areas. Moreover, hypometabolism in these brain regions was a predictor of phenoconversion to PD or DLB. Evaluation of cognitive function and neuroimaging characteristics could be useful for risk stratification in patients with iRBD.AD=Alzheimer disease; ChEI=cholinesterase inhibitor; CIS=cingulate island sign; COWAT=Controlled Oral Word Association Test; CWST=Color–Word Stroop Test; DLB=dementia with Lewy bodies; dnPDRBD-RP=de novo Parkinson disease with prolonged REM sleep behavior disorder symptoms before developing parkinsonism; FDG=18F-fluorodeoxyglucose; FWE=family-wise error; FWHM=full width at half maximum; GLM=general linear model; HC=healthy control; HR=hazard ratio; iRBD=isolated REM sleep behavior disorder; K-BNT=Korean version of the Boston Naming Test; LB=Lewy bodies; MCI=mild cognitive impairment; MDS=Movement Disorder Society; MDS-UPDRS=Movement Disorder Society–sponsored revision of the Unified Parkinson’s Disease Rating Scale; MMSE=Mini-Mental State Examination; MNI=Montreal Neurological Institute; MPS=mild parkinsonian signs; MSA=multiple system atrophy; NC=normal cognition; PD=Parkinson disease; RBD=REM sleep behavior disorder; RBDRP=REM sleep behavior disorder–related brain metabolic pattern; RCFT=Rey-Osterrieth Complex Figure Test; ROI=region of interest; SVLT=Seoul Verbal Learning Test; TFCE=threshold-free cluster enhancement; TMT=Trail-Making Test ER -