% 0期刊文章% Joonsang Yoo %一个Jee Kim Hyun % Jimin全% Tae-Jin歌曲Jinkwon金正日% % T COVID-19感染和严重的并发症的风险在癫痫患者% B一个全国性的队列研究% D R 10.1212 / WNL 2022%。0000000000200195 % J半岛投注体育官网神经病学% P e1886-e1892 % V 98% N 19% X背景和目标这项工作的目的是评估是否癫痫患者更容易冠状病毒疾病2019 (COVID-19)感染和严重的并发症的风险更大的患者相比,当感染COVID-19没有癫痫。方法包括参与者接受至少1严重急性呼吸系统综合症冠状病毒2实时逆转录聚合酶链反应测试1月1日至6月4日,2020年,朝鲜全国COVID-19数据集。癫痫的定义根据诊断代码的存在卫生索赔数据COVID-19前诊断。探讨癫痫的易感性之间的关系或严重并发症COVID-19, 1:6的比例倾向得分匹配(PSM)并进行逻辑回归分析。严重的并发症与COVID-19感染发病率的被定义为一个复合机械通风,重症监护室住院和死亡后2个月内COVID-19诊断。结果212678名研究参与者接受了COVID-19测试中,3919(1.8%)有癫痫史。PSM之后,没有显著差异COVID-19 PCR积极根据癫痫历史(比值比(或)0.86,95% CI 0.67 - -1.11)。COVID-19确诊的7713人感染,72人(0.9%)有癫痫史。COVID-19患者,严重的并发症发生在444年(5.8%)的人。PSM后,癫痫的存在与COVID-19感染后严重的并发症的发生(或2.05,95%可信区间1.04 - -4.04)。死亡率COVID-19感染后没有根据癫痫的存在历史差异(或1.55,95%可信区间0.65 - -3.70)。Discussion The presence of epilepsy was not associated with increased susceptibility to COVID-19 infection or mortality related to the infection. However, there was an increased risk of severe complications with COVID-19 in patients with epilepsy; therefore, careful management and monitoring may be necessary.COVID-19=coronavirus disease 2019; ICD-10=International Statistical Classification of Diseases and Related Health Problems, 10th revision; ICU=intensive care unit; NHIS=National Health Insurance Service; OR=odds ratio; PSM=propensity score matching; RT-PCR=reverse-transcription PCR; SMD=standardized mean difference %U //www.ebmtp.com/content/neurology/98/19/e1886.full.pdf