% 0期刊文章%伊利亚Sechi %卡尔·n·Krecke % Steven A .梅西纳%码头Buciuc %肖恩·j·Pittock %约翰·j·陈%布莱恩·g·Weinshenker %一个克劳迪娅·f·A·塞巴斯蒂安Lopez-Chiriboga % Lucchinetti %尼古拉斯·l·Zalewski % 1月Mendelt Tillema %一个萨尔瓦多摩纳哥艾米Kunchok % %最后p·莫里斯%一个詹姆斯p炸锅%亚当阮% Tammy Greenwood % b斯蒂芬妮。Syc-Mazurek % b . Eoin p·弗拉纳根马克Keegan % % T MRI病灶进化的比较在不同的中枢神经系统脱髓鞘疾病% D R 10.1212 / WNL 2021%。0000000000012467 % J半岛投注体育官网神经病学% P e1097-e1109 % V 97% N 11% X背景和目标有一些研究比较损伤演化不同中枢神经系统脱髓鞘疾病,然而,这可能是重要的诊断知识和理解疾病发病机理的差异。我们试图比较MRI T2损伤演化在髓少突细胞糖蛋白G免疫球蛋白(免疫球蛋白)相关的障碍(MOGAD),水通道蛋白4 IgG-positive neuromyelitis视谱系障碍(AQP4-IgG-NMOSD)和多发性硬化症(MS)。本描述性研究方法,我们回顾性MOGAD患者梅奥诊所,AQP4-IgG-NMOSD,或者女士和(1)脑脊髓炎攻击;(2)可用攻击MRI在6周内;和(3)随访MRI超过6个月没有复发间隔。两个神经病学家确定每个病人的症状或最大T2病灶病变(索引)。核磁共振成像是独立审核2神经放射蒙蔽T2病灶的诊断,以确定解决方案的共识。索引T2病灶区域手动敏锐地概述和在随访评估变化的大小。结果包括156例(MOGAD 38;AQP4-IgG-NMOSD 51;女士,67)与172年攻击(大脑,81;脊髓炎,91)。 The age (median [range]) differed between MOGAD (25 [2–74]), AQP4-IgG-NMOSD (53 [10–78]), and MS (37 [16–61]) (p < 0.01) and female sex predominated in the AQP4-IgG-NMOSD (41/51 [80%]) and MS (51/67 [76%]) groups but not among those with MOGAD (17/38 [45%]). Complete resolution of the index T2 lesion was more frequent in MOGAD (brain, 13/18 [72%]; spine, 22/28 [79%]) than AQP4-IgG-NMOSD (brain, 3/21 [14%]; spine, 0/34 [0%]) and MS (brain, 7/42 [17%]; spine, 0/29 [0%]) (p < 0.001). Resolution of all T2 lesions occurred most often in MOGAD (brain, 7/18 [39%]; spine, 22/28 [79%]) than AQP4-IgG-NMOSD (brain, 2/21 [10%]; spine, 0/34 [0%]) and MS (brain, 2/42 [5%]; spine, 0/29 [0%]) (p < 0.01). There was a larger median (range) reduction in T2 lesion area in mm2 on follow-up axial brain MRI with MOGAD (213 [55–873]) than AQP4-IgG-NMOSD (104 [0.7–597]) (p = 0.02) and MS (36 [0–506]) (p < 0.001) and the reductions in size on sagittal spine MRI follow-up in MOGAD (262 [0–888]) and AQP4-IgG-NMOSD (309 [0–1885]) were similar (p = 0.4) and greater than in MS (23 [0–152]) (p < 0.001).Discussion The MRI T2 lesions in MOGAD resolve completely more often than in AQP4-IgG-NMOSD and MS. This has implications for diagnosis, monitoring disease activity, and clinical trial design, while also providing insight into pathogenesis of CNS demyelinating diseases.AQP4=aquaporin 4; AQP4-IgG-NMOSD=aquaporin 4–immunoglobulin G–positive neuromyelitis optica spectrum disorder; EDSS=Expanded Disability Status Scale; FLAIR=fluid-attenuated inversion recovery; IgG=immunoglobulin G; IVIg=IV immunoglobulin; MOG=myelin oligodendrocyte glycoprotein; MOGAD=myelin oligodendrocyte glycoprotein–immunoglobulin G–associated disorder; MS=multiple sclerosis; PLEX=plasma exchange %U //www.ebmtp.com/content/neurology/97/11/e1097.full.pdf