@article {Sechie1097作者={伊利亚Sechi和卡尔·n·Krecke史蒂文·a·梅西纳和滨Buciuc肖恩·j·Pittock和约翰·j·陈和布莱恩·g·Weinshenker和a·塞巴斯蒂安Lopez-Chiriboga克劳迪娅·f·Lucchinetti和尼古拉斯·l·Zalewski Jan Mendelt Tillema和艾米Kunchok和萨尔瓦多摩纳哥和最后p·莫里斯和詹姆斯·p·弗莱尔和亚当阮Tammy Greenwood和斯蒂芬妮·b·Syc-Mazurek b .马克基冈和Eoin p·弗拉纳根},title = {MRI病灶进化的比较在不同的中枢神经系统脱髓鞘疾病},体积={97}={11},页面= {e1097——e1109} = {2021}, doi = {10.1212 / WNL。出版商0000000000012467}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标有一些研究比较损伤演化不同中枢神经系统脱髓鞘疾病,然而,这可能是重要半岛投注体育官网的诊断知识和理解疾病发病机理的差异。我们试图比较MRI T2损伤演化在髓少突细胞糖蛋白G免疫球蛋白(免疫球蛋白){\ textendash}相关障碍(MOGAD),水通道蛋白4免疫球蛋白{\ textendash}积极neuromyelitis视谱系障碍(AQP4-IgG-NMOSD)和多发性硬化症(MS)。本描述性研究方法,我们回顾性MOGAD患者梅奥诊所,AQP4-IgG-NMOSD,或者女士和(1)脑脊髓炎攻击;(2)可用攻击MRI在6周内;和(3)随访MRI超过6个月没有复发间隔。两个神经病学家确定每个病人的症状或最大T2病灶病变(索引)。核磁共振成像是独立审核2神经放射蒙蔽T2病灶的诊断,以确定解决方案的共识。索引T2病灶区域手动敏锐地概述和在随访评估变化的大小。结果包括156例(MOGAD 38;AQP4-IgG-NMOSD 51;女士,67)与172年攻击(大脑,81;脊髓炎,91)。 The age (median [range]) differed between MOGAD (25 [2{\textendash}74]), AQP4-IgG-NMOSD (53 [10{\textendash}78]), and MS (37 [16{\textendash}61]) (p \< 0.01) and female sex predominated in the AQP4-IgG-NMOSD (41/51 [80\%]) and MS (51/67 [76\%]) groups but not among those with MOGAD (17/38 [45\%]). Complete resolution of the index T2 lesion was more frequent in MOGAD (brain, 13/18 [72\%]; spine, 22/28 [79\%]) than AQP4-IgG-NMOSD (brain, 3/21 [14\%]; spine, 0/34 [0\%]) and MS (brain, 7/42 [17\%]; spine, 0/29 [0\%]) (p \< 0.001). Resolution of all T2 lesions occurred most often in MOGAD (brain, 7/18 [39\%]; spine, 22/28 [79\%]) than AQP4-IgG-NMOSD (brain, 2/21 [10\%]; spine, 0/34 [0\%]) and MS (brain, 2/42 [5\%]; spine, 0/29 [0\%]) (p \< 0.01). There was a larger median (range) reduction in T2 lesion area in mm2 on follow-up axial brain MRI with MOGAD (213 [55{\textendash}873]) than AQP4-IgG-NMOSD (104 [0.7{\textendash}597]) (p = 0.02) and MS (36 [0{\textendash}506]) (p \< 0.001) and the reductions in size on sagittal spine MRI follow-up in MOGAD (262 [0{\textendash}888]) and AQP4-IgG-NMOSD (309 [0{\textendash}1885]) were similar (p = 0.4) and greater than in MS (23 [0{\textendash}152]) (p \< 0.001).Discussion The MRI T2 lesions in MOGAD resolve completely more often than in AQP4-IgG-NMOSD and MS. This has implications for diagnosis, monitoring disease activity, and clinical trial design, while also providing insight into pathogenesis of CNS demyelinating diseases.AQP4=aquaporin 4; AQP4-IgG-NMOSD=aquaporin 4{\textendash}immunoglobulin G{\textendash}positive neuromyelitis optica spectrum disorder; EDSS=Expanded Disability Status Scale; FLAIR=fluid-attenuated inversion recovery; IgG=immunoglobulin G; IVIg=IV immunoglobulin; MOG=myelin oligodendrocyte glycoprotein; MOGAD=myelin oligodendrocyte glycoprotein{\textendash}immunoglobulin G{\textendash}associated disorder; MS=multiple sclerosis; PLEX=plasma exchange}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/97/11/e1097}, eprint = {//www.ebmtp.com/content/97/11/e1097.full.pdf}, journal = {Neurology} }