RT期刊文章SR电子T1 Leptomeningeal钆增强整个光谱的慢性神经炎症疾病摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1439 OP 1444 10.1212 / WNL。半岛投注体育官网88签证官0000000000003820 15 A1玛蒂娜Absinta A1艾琳蔡玫Cortese A1路易莎Vuolo A1 Govind Nair A1 Manori p . de Alwis A1琼Ohayon A1亚历山德罗代表我A1维Martinelli A1罗伯塔Scotti A1 Andrea Falini A1布莱恩·r .史密斯A1 Avindra Nath A1史蒂文·雅各布森A1马西莫菲利皮主持A1丹尼尔s帝国年2017 UL //www.ebmtp.com/content/88/15/1439.abstract AB目的:评估患病率和leptomeningeal增强(LME)的特异性postcontra半岛投注体育官网st T2-fluid-attenuated反转恢复(天赋)MRI在多发性硬化症(MS)检测不到发炎与多种炎症和迹象神经条件评估2学术研究医院。方法:在3 t postcontrast T2-FLAIR图像、焦钆增强的存在是评估254年leptomeningeal室非ms患者神经条件或亲神经的病毒感染。基于他们的临床诊断,患者分组如下:(1)other-than-MS炎症性神经疾病;检测不到发炎(2)迹象神经系统疾病;(3)人类t细胞白血病病毒(HTLV)来华的;(4)艾滋病毒感染;(5)健康志愿者。结果:LME中检测出非MS 56/254例(22%)和74/299(25%)的情况下女士。LME将近4倍更频繁的在非ms炎症神经条件下检测不到发炎(18/51例,35%)比迹象神经条件(3/38,8%)和健康志愿者(5/66,8%)。LME检测人体t细胞白血病病毒感染的患病率最高(17/38例,45%),尤其是在设置HTLV-associated脊髓病(14/25例,56%)。 LME also frequently occurred in HIV infection (13/61 cases, 21%). Unlike in MS, LME is not associated with lower brain and cortical volumes in non-MS inflammatory neurologic conditions, including HTLV and HIV infection.Conclusions: Despite its relevance to MS pathogenesis and cortical pathology, LME is not specific to MS, occurring frequently in non-MS inflammatory neurologic conditions and especially in those patients with HTLV-associated myelopathy. Overall, this strengthens the notion that LME localizes inflammation-related focal disruption of the blood–meninges barrier and associated scarring.CI=confidence interval; FLAIR=fluid-attenuated inversion recovery; HAM/TSP=human T-lymphotropic virus–associated myelopathy/tropical spastic paraparesis; HTLV=human T-lymphotropic virus; LME=leptomeningeal enhancement; LP=lumbar puncture; MS=multiple sclerosis; OR=odds ratio; WM=white matter