% 0期刊文章%马蒂娜Absinta %艾琳蔡玫Cortese %一个Govind Nair路易莎Vuolo % % Manori p . de Alwis %一个亚历桑德罗·琼Ohayon %代表我%一维Martinelli %一个Andrea Falini罗伯塔Scotti % %一个布莱恩·R·史密斯% Avindra Nath %史蒂文·雅各布森%一个丹尼尔·马西莫菲利皮主持% s帝国% T Leptomeningeal钆增强整个光谱的慢性神经炎症疾病% D R 10.1212 / WNL 2017%。0000000000003820 % J半岛投注体育官网神经病学% P 1439 - 1444 X % V 88% N 15%目的:评估患病率和leptomeningeal增强(LME)的特异性postcontrast T2-fluid-attenuated反转恢复(天赋)MRI在多发性硬化症(MS)检测不到发炎与多种炎症和迹象神经条件评估2学术研究医院。方法:在3 t postcontrast T2-FLAIR图像、焦钆增强的存在是评估254年leptomeningeal室非ms患者神经条件或亲神经的病毒感染。基于他们的临床诊断,患者分组如下:(1)other-than-MS炎症性神经疾病;检测不到发炎(2)迹象神经系统疾病;(3)人类t细胞白血病病毒(HTLV)来华的;(4)艾滋病毒感染;(5)健康志愿者。结果:LME中检测出非MS 56/254例(22%)和74/299(25%)的情况下女士。LME将近4倍更频繁的在非ms炎症神经条件下检测不到发炎(18/51例,35%)比迹象神经条件(3/38,8%)和健康志愿者(5/66,8%)。LME检测人体t细胞白血病病毒感染的患病率最高(17/38例,45%),尤其是在设置HTLV-associated脊髓病(14/25例,56%)。LME也常常发生在艾滋病毒感染(13/61例,21%)。 Unlike in MS, LME is not associated with lower brain and cortical volumes in non-MS inflammatory neurologic conditions, including HTLV and HIV infection.Conclusions: Despite its relevance to MS pathogenesis and cortical pathology, LME is not specific to MS, occurring frequently in non-MS inflammatory neurologic conditions and especially in those patients with HTLV-associated myelopathy. Overall, this strengthens the notion that LME localizes inflammation-related focal disruption of the blood–meninges barrier and associated scarring.CI=confidence interval; FLAIR=fluid-attenuated inversion recovery; HAM/TSP=human T-lymphotropic virus–associated myelopathy/tropical spastic paraparesis; HTLV=human T-lymphotropic virus; LME=leptomeningeal enhancement; LP=lumbar puncture; MS=multiple sclerosis; OR=odds ratio; WM=white matter %U //www.ebmtp.com/content/neurology/88/15/1439.full.pdf