@article {Absinta1439作者={玛蒂娜Absinta艾琳、蔡玫Cortese和路易莎Vuolo Govind Nair Manori p . de Alwis和琼Ohayon亚历山德罗代表我和维托里奥Martinelli罗伯塔Scotti Andrea Falini和布莱恩·r·史密斯和Avindra Nath史蒂文·雅各布森和马西莫菲利皮主持和丹尼尔s帝国},title = {Leptomeningeal钆增强整个光谱的慢性神经炎症疾病},体积={88}={15},页面= {1439 - 1444}= {2017},doi = {10.1212 / WNL。出版商0000000000003820}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:评估患病率和leptomeningeal增强(LME)的特异性postc半岛投注体育官网ontrast T2 {\ textendash} fluid-attenuated反转恢复(天赋)MRI在多发性硬化症(MS)检测不到发炎与多种炎症和迹象神经条件评估2学术研究医院。方法:在3 t postcontrast T2-FLAIR图像、焦钆增强的存在是评估254年leptomeningeal室非ms患者神经条件或亲神经的病毒感染。基于他们的临床诊断,患者分组如下:(1)other-than-MS炎症性神经疾病;检测不到发炎(2)迹象神经系统疾病;(3)人类t细胞白血病病毒(HTLV) {\ textendash}感染;(4)艾滋病毒感染;(5)健康志愿者。结果:LME中检测出非MS 56/254例(22 \ %)与74/299(25 \ %)女士的案件。LME将近4倍更频繁的在非ms炎症神经条件(18/51例,35 \ %)检测不到发炎的迹象神经条件(3/38,8 \ %)和健康志愿者(5/66,8 \ %)。LME检测人体t细胞白血病病毒感染的患病率最高(17/38的情况下,45 \ %),特别是在设置HTLV-associated脊髓病(14/25的情况下,56 \ %)。LME也常常发生在艾滋病毒感染(13/61的情况下,21 \ %)。 Unlike in MS, LME is not associated with lower brain and cortical volumes in non-MS inflammatory neurologic conditions, including HTLV and HIV infection.Conclusions: Despite its relevance to MS pathogenesis and cortical pathology, LME is not specific to MS, occurring frequently in non-MS inflammatory neurologic conditions and especially in those patients with HTLV-associated myelopathy. Overall, this strengthens the notion that LME localizes inflammation-related focal disruption of the blood{\textendash}meninges barrier and associated scarring.CI=confidence interval; FLAIR=fluid-attenuated inversion recovery; HAM/TSP=human T-lymphotropic virus{\textendash}associated myelopathy/tropical spastic paraparesis; HTLV=human T-lymphotropic virus; LME=leptomeningeal enhancement; LP=lumbar puncture; MS=multiple sclerosis; OR=odds ratio; WM=white matter}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/88/15/1439}, eprint = {//www.ebmtp.com/content/88/15/1439.full.pdf}, journal = {Neurology} }