TY - JOUR T1 -成人CNS MOG自身免疫的临床谱及预后价值JF -神经学JO -神经学SP - e1858 LP - e1869 DO - 10.1212/WNL.0000半岛投注体育官网000000005560六世- 90 - 21盟Cobo-Calvo Alvaro AU -鲁伊斯,安妮盟——Maillart伊丽莎白盟——Audoin Bertrand盟——Zephir Helene盟——Bourre Bertrand盟——Ciron乔纳森•AU - Collongues尼古拉斯盟——Brassat大卫盟——棉花,弗朗索瓦•AU - Papeix卡罗琳AU - Durand-Dubief,弗朗索瓦丝盟——Laplaud大卫AU -德尚,罗曼AU -科恩,米凯尔盟——Biotti Damien盟——Ayrignac Xavier盟——Tilikete卡罗琳盟——Thouvenot Eric AU -布罗谢,布鲁诺AU - Dulau,塞西尔盟——男人味儿,蒂博AU - Tourbah，艾曼AU - Lebranchu，皮埃尔AU - Michel，劳尔AU - Lebrun-Frenay，克里斯汀AU - Montcuquet，亚历克西斯AU - Mathey，纪尧姆AU - Debouverie，马克AU - Pelletier，让AU AU - Labauge，皮埃尔AU - Derache，娜塔莉AU - Coustans，马克AU - Rollot，法比安AU - De Seze, Jérôme AU - Vukusic，桑德拉AU - Marignier，Romain Y1 - 2018/05/22 UR - http://n.半岛投注体育官网neurology.org/content/90/21/e1858.abstract N2 -目的描述法国全国大型成人队列中髓鞘少突胶质细胞糖蛋白抗体(MOG-Ab)相关的临床和放射学特征，评估首次急性脱髓鞘综合征后MOG-Ab相关疾病的基线预后特征，并评估MOG-Ab纵向分析的临床价值。方法收集197例年龄≥18岁mog - ab阳性患者的临床资料。108例患者有完整的影像学数据，54例血清样本符合纵向评价条件。为了进行生存分析比较，从NOMADMUS数据库中纳入169例水通道蛋白-4抗体(AQP4-Ab)阳性患者。中位发病年龄为36.46岁(18.0-76.8岁)，患者以白人为主(92.9%)，男女比例为1.1。发病时的临床表型包括视神经炎或脊髓炎(90.86%)，单独的脑干或脑病综合征(6.6%)，综合征组合(2.5%)。mog - ab阳性患者的脑MRI表现为丘脑和桥脑病变。皮质和轻脑膜病变分别为16.3%和6.1%。 The probability of reaching a first relapse after 2 and 5 years was 44.8% and 61.8%, respectively. MOG-Ab-positive patients were at lower risk at presentation of further clinical relapse (hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.26–0.79) compared to AQP4-Ab-positive individuals. MOG-Ab-positive individuals had a lower risk of reaching Disability Status Scale score of 3.0 (HR 0.46, 95% CI 0.22–0.94) and visual acuity of 20/100 (HR 0.23, 95% CI 0.07–0.72). Finally, MOG-Ab titers were higher at relapse than in remission (p = 0.009).Conclusion In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord. Despite the relapsing course, the overall visual and motor outcome is better compared with AQP4-Ab-positive patients.ADS=acquired demyelinating syndromes; AQP4-Ab=aquaporin-4 antibodies; CI=confidence interval; DSS=Disability Status Scale; EDSS=Expanded Disability Status Scale; FLAIR=fluid-attenuated inversion recovery; HR=hazard ratio; IgG=immunoglobulin G; IQR=interquartile range; MOG-Ab=myelin oligodendrocyte glycoprotein antibodies; MS=multiple sclerosis; NMOSD=neuromyelitis optica spectrum disorder; OCB=oligoclonal band; OFSEP=Observatoire Français de la Sclérose en Plaques; ON=optic neuritis; TM=transverse myelitis; VA=visual acuity ER -