0杂志文章科博-卡尔沃，阿尔瓦罗·鲁伊斯，安妮·玛拉特，伊丽莎白·奥登，伯特兰·泽菲尔，海伦娜·布尔雷，伯特兰·西隆，乔纳森·科隆格，尼古拉斯·布拉萨特，大卫·科顿，弗朗索瓦·帕佩克斯，卡罗琳·杜朗-杜比夫，弗朗索瓦丝·拉普劳德，大卫·德尚，罗曼·科恩，Mikaël比奥蒂，达米恩·埃里尼亚克，泽维尔·蒂利克特，卡罗琳·索维诺，埃里克·布罗谢，布鲁诺·杜罗，塞西尔·莫罗，蒂博·图尔巴，艾曼·勒布兰楚，Pierre Michel, Laure Lebrun-Frenay, Christine Montcuquet, Alexis Mathey, Guillaume Debouverie, Marc Pelletier, Jean Labauge, Pierre Derache, Nathalie Coustans, Marc Rollot, Fabien De Seze, Jérôme Vukusic, Sandra Marignier, Romain成人CNS MOG自身免疫的临床谱和预后价值%D 2018 %R 10.1212/WNL。目的描述法国全国成人队列中髓鞘少突胶质细半岛投注体育官网胞糖蛋白抗体(MOG-Ab)相关的临床和放射学特征，评估第一例急性脱髓鞘综合征后MOG-Ab相关疾病的基线预后特征，并评估MOG-Ab纵向分析的临床价值。方法收集197例年龄≥18岁mog - ab阳性患者的临床资料。108例患者有完整的影像学数据，54例血清样本符合纵向评价条件。为了进行生存分析比较，从NOMADMUS数据库中纳入169例水通道蛋白-4抗体(AQP4-Ab)阳性患者。中位发病年龄为36.46岁(18.0-76.8岁)，患者以白人为主(92.9%)，男女比例为1.1。发病时的临床表型包括视神经炎或脊髓炎(90.86%)，单独的脑干或脑病综合征(6.6%)，综合征组合(2.5%)。mog - ab阳性患者的脑MRI表现为丘脑和桥脑病变。皮质和轻脑膜病变分别为16.3%和6.1%。2年和5年后首次复发的概率分别为44.8%和61.8%。 MOG-Ab-positive patients were at lower risk at presentation of further clinical relapse (hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.26–0.79) compared to AQP4-Ab-positive individuals. MOG-Ab-positive individuals had a lower risk of reaching Disability Status Scale score of 3.0 (HR 0.46, 95% CI 0.22–0.94) and visual acuity of 20/100 (HR 0.23, 95% CI 0.07–0.72). Finally, MOG-Ab titers were higher at relapse than in remission (p = 0.009).Conclusion In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord. Despite the relapsing course, the overall visual and motor outcome is better compared with AQP4-Ab-positive patients.ADS=acquired demyelinating syndromes; AQP4-Ab=aquaporin-4 antibodies; CI=confidence interval; DSS=Disability Status Scale; EDSS=Expanded Disability Status Scale; FLAIR=fluid-attenuated inversion recovery; HR=hazard ratio; IgG=immunoglobulin G; IQR=interquartile range; MOG-Ab=myelin oligodendrocyte glycoprotein antibodies; MS=multiple sclerosis; NMOSD=neuromyelitis optica spectrum disorder; OCB=oligoclonal band; OFSEP=Observatoire Français de la Sclérose en Plaques; ON=optic neuritis; TM=transverse myelitis; VA=visual acuity %U //www.ebmtp.com/content/neurology/90/21/e1858.full.pdf