文章数据和数据
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图1 径向和轴向的例子测量脊髓和大脑区域T2病灶
左边的图中显示矢状(的一部分。一个。b, b。a) and axial (A.c, B.b) T2-weighted images of a longitudinally extensive spinal cord lesion associated with aquaporin 4–immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD) acutely (A) and at follow-up (B). The largest acute axial area of the lesion was manually outlined acutely on sagittal (A.b, yellow outline) and axial (A.d, yellow outline) images and at follow-up (B.c) to determine lesion resolution/reduction. In the center of the figure, an acute brainstem T2-hyperintense lesion associated with myelin oligodendrocyte glycoprotein–immunoglobulin G–associated disorder (MOGAD) is shown on axial fluid-attenuated inversion recovery images (C.a). The largest axial T2 lesion area manually outlined acutely (C.b, yellow outline) resolves to undetectable at follow-up MRI (D). On the right, a multiple sclerosis (MS) myelitis T2-hyperintense lesion is shown (E.a, E.b) with the largest area of the T2-hyperintense lesion outlined acutely on both sagittal (E.b, yellow outline) and axial (E.d, yellow outline) images. Despite being smaller acutely compared to the lesions associated with AQP4-IgG-NMOSD and MOGAD, the MS lesion only shows moderate reduction in size at follow-up, where it is still clearly visible on both sagittal (F.a, yellow outline) and axial (F.b, F.c, yellow outline) images.
轴向fluid-attenuated反转恢复infratentorial (A, C, E)和幕上的(B, D, F)脑部MRI显示。AQP4-IgG-NMOSD患者(A、B),大急性病变。a、B。a) commonly show a prominent reduction of their initial size but rarely resolve completely, typically leaving tiny residual abnormalities (A.b, B.b; red circles). In patients with MOGAD (C, D), most large acute T2-hyperintense lesions (C.a, D.a) resolve to undetectable (C.b) at follow-up MRI, although some acute T2 lesions can leave some (often nonspecific) small foci of T2 hyperintensity (D.b; red circle). In patients with MS (E, F), acute T2-hyperintense lesions are relatively smaller (E.a, F.a) and typically show moderate reduction in size at follow-up, while remaining clearly detectable (E.b, F.b; red circles).
矢状(A。a、B。a, C。a, D。a, E。F。a) and axial (A.b, B.b, C.b, D.b, E.b, F.b) thoracic spinal cord T2-weighted images are shown. In patients with myelitis, T2-hyperintense lesions associated with AQP4-IgG-NMOSD, longitudinally extensive lesions with swelling of the spinal cord (A.a) and holocord involvement acutely (A.b [T7 vertebral body level]), frequently show a dramatic reduction in size at follow-up MRI but remain detectable, often accompanied by focal lesional spinal cord atrophy (B.a, B.b [T7 vertebral body level]). In patients with MOGAD myelitis, the acute ventral-predominant long T2 lesion extending to the conus (C.a) is gray matter restricted axially (C.b [T3 vertebral body level]) and resolved completely at follow-up MRI (D.a, D.b [T3 vertebral body level]). In patients with MS, the typically short acute myelitis T2-hyperintense lesion (E.a, E.b [T6-T7 vertebral body level]) often only has modest reduction in size at follow-up MRI (F.a, F.b [T6-T7 vertebral body level]), at which time it can be better appreciated to involve the periphery (right lateral columns) of the spinal cord on axial images (F.b [T6-T7 vertebral body level]).
(A)条图显示了不同的频率分析措施的患者水通道蛋白4-immunoglobulin G-positive neuromyelitis视谱系障碍(AQP4-IgG-NMOSD)(深蓝色酒吧),髓少突细胞glycoprotein-immunoglobulin G-associated障碍(MOGAD)(浅蓝色酒吧)和多发性硬化症(MS)(绿酒吧)在大脑和脊髓。尽管规模最大的减少在AQP4-IgG-NMOSD和MOGAD病变有关,只有后者的MRI异常显示完整的决议后续在大多数情况下。相反,病灶显示的大小会减少最小的女士在随访,类似于AQP4-IgG-NMOSD病变,不太可能完全解决。两组统计学意义差异由星号表示的酒吧(* * *)。(B)中位数为大脑和脊髓损伤轴向最大的区域,并为脊髓矢状,敏锐,MRI随访3组。确切的p所示值不同的比较表2和3。
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信:快速的网络通信
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读者反应:MRI病灶进化的比较在不同的中枢神经系统脱髓鞘疾病
![Spinal Cord MRI Lesion Evolution in Aquaporin 4–Immunoglobulin G–Positive Neuromyelitis Optica Spectrum Disorder (AQP4-IgG-NMOSD), Myelin Oligodendrocyte Glycoprotein–Immunoglobulin G–Associated Disorder (MOGAD), and Multiple Sclerosis (MS) Sagittal (A.a, B.a, C.a, D.a, E.a, F.a) and axial (A.b, B.b, C.b, D.b, E.b, F.b) thoracic spinal cord T2-weighted images are shown. In patients with myelitis, T2-hyperintense lesions associated with AQP4-IgG-NMOSD, longitudinally extensive lesions with swelling of the spinal cord (A.a) and holocord involvement acutely (A.b [T7 vertebral body level]), frequently show a dramatic reduction in size at follow-up MRI but remain detectable, often accompanied by focal lesional spinal cord atrophy (B.a, B.b [T7 vertebral body level]). In patients with MOGAD myelitis, the acute ventral-predominant long T2 lesion extending to the conus (C.a) is gray matter restricted axially (C.b [T3 vertebral body level]) and resolved completely at follow-up MRI (D.a, D.b [T3 vertebral body level]). In patients with MS, the typically short acute myelitis T2-hyperintense lesion (E.a, E.b [T6-T7 vertebral body level]) often only has modest reduction in size at follow-up MRI (F.a, F.b [T6-T7 vertebral body level]), at which time it can be better appreciated to involve the periphery (right lateral columns) of the spinal cord on axial images (F.b [T6-T7 vertebral body level]).](http://www.ebmtp.com/content/neurology/97/11/e1097/F3.large.jpg?width=800&height=600&carousel=1){kind=link}
