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In the Research Article entitled “Midlife Systemic Inflammatory Markers Are Associated With Late-Life Brain Volume: The ARIC Study” by Walker et al.,1 a series of coding errors affected the statistical analyses used to generate the results of the article. The authors corrected the errors and reanalyzed the original data. They do not believe the errors changed the overall message in the article that midlife inflammation is associated with lower late-life brain volume. Below, the errors are summarized with how the corrected results differ. Identified errors in the original code include the misclassification of a nominal covariate (center race) as ordinal, use of the alcohol use covariate from a later visit (rather than baseline), and an error in the scaling of the beta coefficients.
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