CNS T-Cell Lymphoma Many Years After Hemophagocytic Lymphohistiocytosis
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A 26-year-old man presented with 2 months of progressive encephalopathy, right inferior quadrantanopia, right hemiparesis, and facial swelling (Figure, A and B). An MRI of the brain revealed an enhancing left parietal lesion (Figure, C–E). Fluorodeoxyglucose-PET demonstrated hypermetabolism in the left parietal lesion, face, and abdominal musculature (Figure, F–G). Abdominal muscle, face, and left parietal lesion biopsies confirmed CD8+, CD30− T-cell lymphoma. His lymphoma improved with methotrexate and temozolomide (Figure, H and I).
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Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
The handling editor was Editor-in-Chief José G. Merino, MD, MPhil, FAHA, FAAN.
- Received November 15, 2022.
- Accepted in final form February 16, 2023.
- © 2023 American Academy of Neurology
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