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遗传适度β-Amyloid协会的认知和MRI在阿尔茨海默病大脑结构
Philip s . Insel,Atul Kumar,奥斯卡·汉森,视图ORCID概要Niklas Mattsson-Carlgren,阿尔茨海默病的神经影像学
第一次出版2023年4月21日,
DOI: https://doi.org/10.1212/WNL.0000000000207305
Philip s . Insel
从临床记忆研究单位身分,A.K.,平炉,N.M.-C.), Faculty of Medicine, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences (P.S.I.), University of California, San Francisco; Memory Clinic (O.H.), Department of Neurology (N.M.-C.), Skåne University Hospital, and Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University, Sweden.
Atul Kumar
从临床记忆研究单位身分,A.K.,平炉,N.M.-C.), Faculty of Medicine, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences (P.S.I.), University of California, San Francisco; Memory Clinic (O.H.), Department of Neurology (N.M.-C.), Skåne University Hospital, and Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University, Sweden.
奥斯卡·汉森
从临床记忆研究单位身分,A.K.,平炉,N.M.-C.), Faculty of Medicine, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences (P.S.I.), University of California, San Francisco; Memory Clinic (O.H.), Department of Neurology (N.M.-C.), Skåne University Hospital, and Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University, Sweden.
Niklas Mattsson-Carlgren
从临床记忆研究单位身分,A.K.,平炉,N.M.-C.), Faculty of Medicine, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences (P.S.I.), University of California, San Francisco; Memory Clinic (O.H.), Department of Neurology (N.M.-C.), Skåne University Hospital, and Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University, Sweden.
从临床记忆研究单位身分,A.K.,平炉,N.M.-C.), Faculty of Medicine, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences (P.S.I.), University of California, San Francisco; Memory Clinic (O.H.), Department of Neurology (N.M.-C.), Skåne University Hospital, and Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University, Sweden.
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文章数据和数据
数据
图2
区域位点
区域块A4的每个基因变异的位点。选择变体所示紫色。R2值的颜色来反映连锁不平衡的大小。A4 =种抗体治疗无症状的阿尔茨海默病。
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图3
扣带皮层部位的分数在A4
扣带皮层部位分数策划针对18 f-florbetapir SUVRs A4为每个4变种。单独的曲线显示了参与者携带小等位基因的遗传变异(问+)和非(问−)。阴影区域表示95%的CIs。A4 =种抗体治疗无症状的阿尔茨海默病;扣带皮层部位=临床前阿尔茨海默认知复合。
图4
扣带皮层部位分数和结构磁共振成像
参与者的代表性的扣带皮层部位得分A4策划反对18 f-florbetapir SUVRs通过载体状态变量rs76366637左上角的面板。纵向ADNI参与者的扣带皮层部位比分是随着时间的推移,绘制在右上角面板中,估计曲线和95% CIs 4组:低淀粉样问航空公司蓝色、低淀粉样问非黑,高淀粉样问非黄金,和高淀粉样问航空公司用红色。SUVRs被不断模仿,虽然具体SUVRs用于描述的目的。同样的,在最后一行,纵向心室卷ADNI参与者绘制曲线随着时间的估计和独联体95%相同的4组。A4 =种抗体治疗无症状的阿尔茨海默病;ADNI =阿尔茨海默病神经影像倡议;全球之声=基因变异;扣带皮层部位=临床前阿尔茨海默症的认知复合;SUVR =标准摄入值比率。
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