脑脊液糖脑苷酶活性与帕金森病患者痴呆发病风险的相关性

Distribution of CSF GCase Activity Across the Different Groups GCase activity is shown in control for controls (n = 50) compared with all PD (n = 117), or PD cases divided into idiopathic PD (n = 105) and GBA-PD (n = 12), or PD cases divided into patients with PD with no dementia (n = 76) or PD with dementia (PDD; n = 41). p Values from between-group comparisons are indicated. The boxes indicate the IQR, the horizontal line in each box, the median; whiskers above and below the boxes, 1.5 times the IQR; and circles, outliers. GBA = glucocerebrosidase gene; GCase = glucocerebrosidase; PD = Parkinson disease; PDD = dementia in PD.