协会的Informant-Reported记忆衰退与认知和大脑通过老年痴呆症临床连续恶化

Relationships at Baseline Between I-SMD and Amyloid Deposition and Objective Cognitive or Memory Performances Within the ADNI Replication Cohort Graphs illustrate the results of general linear models for the cross-sectional correlations between the I-SMD w-scores and either the global Florbetapir SUVr across the different stages of the AD clinical continuum (A. p_unadjusted < 0.05 in purple), the Florbetapir-PET in the group of patients with MCI (B. Thresholded at p < 0.001 with a cluster-level correction for multiple comparisons (red) and at p_FWE < 0.05 with a k > 200 voxels (orange); no significant association was found in the other groups), global cognition (C. MMSE w-scores), or verbal episodic memory (D. RAVLT immediate recall w-scores) at baseline. p_unadjusted < 0.10 in pink and p_unadjusted < 0.05 in purple. AD = Alzheimer disease; ADNI = Alzheimer Disease Neuroimaging Initiative; CDS = Cognitive Difficulties Scale; ECog = Everyday Cognition Questionnaire; I-SMD = informant-reported subjective memory decline; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; RAVLT = Rey Auditory Verbal Learning Test; SCD = subjective cognitive decline; SUVr = standardized uptake value ratio.