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2023年5月23日 ;100 (21) 半岛体育app苹果下载 开放获取

睡眠模式和急性中风的风险

结果INTERSTROKE国际病例对照研究

视图ORCID概要克里斯汀•艾琳Mc凯西,Salim Yusuf,视图ORCID概要康纳法官,阿尔贝托Alvarez-Iglesias,视图ORCID概要格雷姆·j .纸巾,Shahram Oveisgharan,视图ORCID概要Albertino Damasceno,赫勒克林根贝格球队,视图ORCID概要安妮卡工厂的,Alvaro Avezum,会长Patricio Lopez-Jaramillo,丹尼斯·泽维尔,Xingyu王,Sumathy Rangarajan周二,马丁·奥唐纳,对于INTERSTROKE
第一次出版2023年4月5日, DOI: https://doi.org/10.1212/WNL.0000000000207249
克里斯汀•艾琳Mc凯西
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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  • 克里斯汀艾琳Mc凯西ORCID纪录
Salim Yusuf
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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康纳法官
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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  • 康纳法官ORCID纪录
阿尔贝托Alvarez-Iglesias
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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格雷姆·j .纸巾
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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  • 格雷姆·j .纸巾ORCID纪录
Shahram Oveisgharan
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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Albertino Damasceno
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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  • ORCID记录Albertino Damasceno
赫勒克林根贝格球队
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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安妮卡工厂的
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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  • 安妮卡罗森格ORCID纪录
Alvaro Avezum
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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会长Patricio Lopez-Jaramillo
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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丹尼斯·泽维尔
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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Xingyu王
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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Sumathy Rangarajan周二
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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马丁·奥唐纳
的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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的药(C.E.M.C.,C.J.,A.A.-I., M.O.D.), University of Galway, Ireland; Department of Medicine (S.Y., S.R.), Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), Faculty of Health and Medical Sciences, University of Western Australia, Perth; Department of Medicine (S.O.), Rush Alzheimer Disease Research Center in Chicago, IL; Faculty of Medicine (A.D.), Eduardo Mondlane University, Maputo, Mozambique; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen, Denmark; Department of Molecular and Clinical Medicine (A.R.), University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Medicine (A.A.), International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil; Department of Medicine (P.L.-J.), Instituto de Investigaciones MASIRA, Universidad de Santander, Bucaramanga, Colombia; Department of Medicine (D.X.), St John's Medical College and Research Institute, Bangalore, India; and Department of Medicine (X.W.), Beijing Hypertension League Institute, China.
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睡眠模式和急性中风的风险
结果INTERSTROKE国际病例对照研究
克里斯汀•艾琳Mc凯西,萨利姆优素福,康纳法官,阿尔贝托。Alvarez-Iglesias,格雷姆·J。纸巾,ShahramOveisgharan,AlbertinoDamasceno,赫勒克林根贝格球队,安妮卡工厂的,AlvaroAvezum,会长PatricioLopez-Jaramillo,丹尼斯泽维尔,Xingyu王,SumathyRangarajan周二,马丁奥唐纳,对于INTERSTROKE
半岛投注体育官网 2023年5月, One hundred. (21) e2191-e2203; DOI:10.1212 / WNL.0000000000207249

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文摘

背景和目标睡眠障碍是常见的症状,可能代表重要修改的患中风的危险因素。我们评估的范围之间的关系睡眠障碍症状和急性中风的风险在国际设置。

方法INTERSTROKE研究是国际第一急性中风患者的病例对照研究和控制相应的年龄(±5年)和性。睡眠症状前一个月通过问卷进行评估。条件逻辑回归估计睡眠障碍症状和急性中风之间的关系,表示为优势比(ORs)和95%的CIs。的主要模型调整年龄、职业、婚姻状况、与后续模型在基线和改良Rankin规模,调整了潜在的介质(行为/疾病危险因素)。

结果总体而言,4496年包括匹配的参与者,1799人有439年经历了缺血性中风和脑内出血。短睡眠(< 5小时:3.15,95% CI 2.09 - -4.76),长时间睡眠(> 9小时:2.67,95% CI 1.89 - -3.78),质量受损(或1.52,95%可信区间1.32 - -1.75),入睡困难(或1.32,95% CI 1.13 - -1.55)或保持睡眠(或1.33,95%可信区间1.15 - -1.53),计划外打盹(或1.48,95%可信区间1.20 - -1.84),长时间的小睡(> 1小时:1.88,95% CI 1.49 - -2.38),打鼾(或1.91,95%可信区间1.62 - -2.24),吸食(或2.64,95%可信区间2.17 - -3.20),和呼吸停止(-3.60或2.87,95% CI 2.28)都显著增加急性中风的几率的主要模型。派生的阻塞性睡眠呼吸暂停2 - 3分(2.67,2.25 - -3.15)和累积睡眠症状(> 5:5.38,4.03 - -7.18)也与急性中风的几率大大增加,后者显示分级协会。一个广泛的调整后,意义是维持大部分症状(不是睡眠/维护困难和计划外午睡),与类似的发现中风亚型。

讨论我们发现,睡眠障碍相关症状很常见和分级增加中风的风险。这些症状可能是个体风险增加的标志或代表独立的危险因素。未来临床试验是必要的,以确定睡眠干预措施预防中风的功效。

术语表

AHEI=
替代健康饮食指数;
身体质量指数=
身体质量指数;
英国石油公司=
血压;
dCBT-I=
数字认知行为疗法;
我=
颅内出血;
夫人=
改良Rankin规模;
或=
优势比;
阻塞性睡眠呼吸暂停综合症=
阻塞性睡眠呼吸暂停;
人民行动党=
气道正压;
索尔=
影响延迟;
WHR=
腰臀比

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  • 去半岛投注体育官网Neurology.org/N为充分披露。资金信息和披露认为作者相关的,如果有的话,年底提供这篇文章。

  • 这篇文章加工费由作者。

  • Coinvestigators列出在links.lww.com/WNL/C722。

  • 提交和外部同行评议。处理编辑器是芭芭拉·Jobst副主编,医学博士,博士FAAN。

  • 信息图表links.lww.com/WNL/C794

  • CME过程:NPub.org/cmelist

  • 收到了2022年8月7日。
  • 接受的最终形式2023年2月16日。
  • 版权©2023年作者(年代)。发表的Wolters Kluwer健康,公司代表美国神经病学学会。半岛投注体育官网

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