文摘
摘要目的:确定参与壁垒和主持人在非洲裔美国人在观察研究阿尔茨海默病及相关痴呆(ADRD)。
背景:非裔美国人经历的高负担ADRD然而极度弱势ADRD研究。持续缺乏表示增加的可能性,研究结果可能不会推广到非裔美国人,包括疗效和安全性试验数据的公认的ADRD-modifying疗法。
设计/方法:电子调查要求受访者对障碍和主持人的研究参与0-3-point李克特规模。反应≥2与障碍/主持人可能影响参与决策。调查问题与非裔美国人社区领导人合作开发的。调查邀请通过社交媒体广告集中分布在周围的邮政编码我们的研究中心。差异在参与者从不同年龄组(18-44 (n = 76);45 - 64 (n = 86)、65 (n = 86) +年)使用非参数克鲁斯卡尔-沃利斯进行评估测试。
结果:248/294完成调查从当地受访者和包含在分析非裔美国人(96.8%)。在所有受访者中,需要经历一个参与诊断腰椎穿刺是最大的障碍(值= 2.0)。个人参加工作日访问了很大障碍18-44(值= 2.0),但不是那些年龄在44 - 64(值= 1.5)或65 +年(值= 0;p = 0.001)。访问的长度(≥2小时)是一个更大的障碍在年轻(值= 2.0)和年长的受访者(值= 1.0;p = 0.001)。参加访问当地社区的能力,在周末,和获得一辆上门服务是实质性的主持人对年轻的受访者(18-44值= 2.0;65 +,中值= 0;p = 0.001)。选择在家完成测试是一个实质性的主持人18 - 64岁(值= 2.0)但不是65 +岁受访者(值= 0; p=0.001). Compensation for meals/transportation were substantial facilitators across all ages (p<0.05).
结论:障碍和主持人ADRD研究参与在年龄谱变化。调查结果会通知特定的策略来解决ADRD研究参与在非洲裔美国人之间的差距
披露:博士把它没有披露。福吉女士没有披露。基督教Lachner没有披露。Graff-Radford博士的机构收到生原体的研究支持。Graff-Radford博士的机构收到莉莉的研究支持。Graff-Radford博士的机构已经收到了诺华的研究支持。Graff-Radford博士的机构已经接到AbbVie研究支持。Graff-Radford博士已经收到相关出版物的出版版税卫生保健。约翰·a·卢卡斯已经收到个人薪酬在500 - 4999美元的范围作为一个军官或董事会成员对美国的临床神经心理学。天已收到博士个人薪酬在5000 - 9999美元的范围为Parabon Nanolabs担任顾问。 The institution of Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for DynaMed (EBSCO Health). Dr. Day has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Barrow Law. Dr. Day has stock in ANI Pharmaceuticals. The institution of Dr. Day has received research support from National Institutes of Health / NIA. The institution of Dr. Day has received research support from Chan Zuckerberg Initiative. The institution of Dr. Day has received research support from Alzheimer’s Association. The institution of Dr. Day has received research support from National Institutes of Health / NINDS. The institution of Dr. Day has received research support from Horizon Therapeutics. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at Annual Meeting (CME) with American Academy of Neurology. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Content Development (CME) with PeerView, Inc. Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Content Development (CME) with Continuing Education, Inc. Dr. Day has a non-compensated relationship as a Clinical Director with AntiNMDA Receptor Encephalitis Foundation that is relevant to AAN interests or activities.
