文摘
摘要目的:确定昼夜步数的关系模式与残疾进展型多发性硬化症(MS)。
背景:恶化扩大残疾状态量表(eds)分数和长时间走25英尺(T25FW)乘以通常对应于增加残疾和女士与较低的日常身体活动。昼夜残疾女士身体活动和发展的模式是可以理解的。
设计/方法:参与者(n = 577)的SPI2研究MD1003(高剂量生物素)在进步,每三个月进行了eds和T25FW 27个月的跟进。Fitbit flex(或flex2)连续监测步骤每分钟计数。记录数据进行了分析使用function-on-scalar回归技术eds, T25FW和其他病人的人口被用来预测平均昼夜步骤。
结果:从12点至8点,eds(意思是R2 = 0.36±0.02)优于T25FW(意思是R2 = 0.26±0.02)在预测每个病人平均昼夜步数曲线在调整了性别、年龄和体重指数。包括eds和T25FW增加意味着R2为0.39±0.02。男性比女性获得5.2%更多的步骤从12点到7点平均而言,虽然女性比男性更多的步骤5.1%从上午10:30分,4.3%从7:30pm到10点平均(p < 0.001)。年龄是最强的影响从下午3点到晚上10点,在每年的年龄与步骤减少0.44% (p < 0.0001)。从上午10点到11点,BMI指数每增加一点翻译步骤减少1.3% (p < 0.0001)。平均日步数在夏天中午波谷,冬天晚上低谷,在春天早晨高峰(p < 0.001)。
结论:降低身体活动之间的关系和残疾指标不是统一天,以及随着季节的变化。这些结果强调需要时机的临床评价研究的一致性,并提供重要的洞察特定时间一天,可能是更可取的有效康复干预措施。
披露:Navani先生已经收到Datavant的个人作为一个雇员补偿。博士没有披露。克里族博士的机构已收到个人薪酬在5000 - 9999美元的范围为Atara担任顾问。克里族博士的机构已收到个人薪酬在5000 - 9999美元的范围作为顾问生原体。克里族博士的机构已收到个人薪酬在10000 - 49999美元的范围为EMD Serono担任顾问。克里族博士的机构已收到个人薪酬在10000 - 49999美元的范围为诺华公司担任顾问。克里族博士的机构已收到个人薪酬在500 - 4999美元的范围为赛诺菲担任顾问。克里族博士的机构已收到个人薪酬在5000 - 9999美元的范围为TG疗法作为顾问。克里族博士的机构已收到个人薪酬在500 - 4999美元的范围作为高速公路的顾问。克里族博士的机构已收到个人薪酬在500 - 4999美元的范围为Avotres担任顾问。 The institution of Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gossamer Bio. Dr. Cree has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Horizon. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neuron23. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Pharma. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Hexal/Sandoz. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Therini. Dr. Cree has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Immunic AG. The institution of Dr. Cree has received research support from Genentech. Dr. Cree has received publishing royalties from a publication relating to health care. Prof. Abbasi-Asl has received research support from NIH. Prof. Abbasi-Asl has received research support from Weill Neurohub.
