2023年4月11日
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一生生殖因素对中风的累积效应及其亚型在绝经后的中国妇女
前瞻性队列研究
莱伊侯,檐沟李,思玉朱,钱易,温刘,你吴,Feitong吴,粤龙记,视图ORCID概要Peige歌,Kazem拉希米
第一次出版2023年2月1日,
DOI: https://doi.org/10.1212/WNL.0000000000206863
莱伊侯
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
檐沟李
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
思玉朱
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
钱易
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
温刘
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
你吴
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
Feitong吴
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
粤龙记
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
Peige歌
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
Kazem拉希米
公共卫生学院和妇女医院(L.H.,S.L.,S.Z.,Q.Y.,柔若,P.S.), Zhejiang University School of Medicine, Hangzhou, China; School of Medicine (Y.W.), Tsinghua University, Institute for Hospital Management, Tsinghua University, Beijing, China; Menzies Institute for Medical Research (F.W.), University of Tasmania, Hobart, Australia; Baker Heart and Diabetes Institute (F.W.), Melbourne, Australia; Department of Maternal and Child Health (Y.J.), School of Public Health, Peking University, Beijing, China; Nuffield Department of Women's & Reproductive Health (K.R.), University of Oxford, United Kingdom; and Deep Medicine Programme (K.R.), Oxford Martin School, University of Oxford, United Kingdom.
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文章数据和数据
数据
图2
指标之间的联系的终身累积雌激素暴露生殖因素和事件发生中风的风险:多变量Cox回归
*p< 0.05。人力资源是调整基线年龄、婚姻状况、居住状况、教育、职业、家庭收入、体重指数、腰围、吸烟、被动吸烟、饮酒、体力活动在代谢当量(h / d),抗凝治疗,降血脂药治疗,糖尿病和高血压。HR =风险比;RLS =生殖寿命;EEE =内源性雌激素暴露;t =总雌激素暴露;是=缺血性中风;我=脑内出血;SAH =蛛网膜下腔出血。
图3
组件之间的协会的终身累积雌激素暴露生殖因素和事件发生中风的风险:多变量Cox回归
*p< 0.05。人力资源在基线调整年龄、婚姻状况、居住状况、教育水平、职业、家庭收入、体重指数、腰围、吸烟、被动吸烟、饮酒、体力活动在代谢当量(h / d),抗凝治疗,降血脂药治疗,糖尿病和高血压。HR =风险比;我=脑内出血;是=缺血性中风;(OCP =口服避孕药;RLS =生殖寿命;SAH =蛛网膜下腔出血。
表
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